孕期肥胖和糖尿病,哪个对后代危害更大?
创作:尹小甜 审核:Epi汪 2020年12月25日
  • 通过转基因技术构建一个新型的老鼠模型,使其在孕前患上糖尿病,并持续到孕期,但是却没有肥胖,比较其与对照组的后代雄鼠情况;
  • 后代雄鼠青少年及成年期的体重增重及血糖水平两组间无统计学差异;
  • 高脂饮食后,两组雄鼠的体重和体脂,以及血糖和胰岛素耐量试验均无统计学差异;
  • 两组雄鼠的血糖控制水平相似可比;
  • 宫内暴露于糖尿病对雄性后代的代谢健康可能没有影响,而其他参数,比如母亲肥胖,可能是引起后代健康损害的关键因素。
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Epi汪
既往的研究认为宫内暴露于母亲肥胖、糖尿病的后代,患代谢性疾病的风险更大。但是有趣的是,母亲的糖尿病和肥胖往往是共存的,很难将损伤效应归因为肥胖还是糖尿病。本研究通过新型的动物模型,构建了孕期糖尿病,但是不肥胖的母亲模型,发现这类小鼠的后代发生代谢性疾病的风险并没有变化。
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Hypertension [IF:7.713]

Intrauterine Exposure to Diabetic Milieu Does Not Induce Diabetes and Obesity in Male Adulthood in a Novel Rat Model

在一个新型的老鼠模型中证明宫内暴露糖尿病并不会引起男性后代的肥胖和糖尿病

10.1161/HYPERTENSIONAHA.120.16360

2020-11-30, Article

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Several studies show an association of maternal diabetes during pregnancy with adverse offspring metabolic health. Other studies, however, suggest that this effect might be biased by obesity, which is independently associated with offspring metabolic disease and often coexistent to maternal diabetes. We performed a prospective study in a rat model to test the hypothesis that the burden of a diabetic pregnancy without obesity deteriorates metabolic health in male offspring. We generated maternal type 2 diabetes before conception that persisted during pregnancy by knockdown of the insulin receptor in small hairpin RNA–expressing transgenic rats. Male WT (wild type) offspring were followed up until adulthood and metabolically challenged by high-fat diet. Blood glucose was measured continuously via a telemetry device. Glucose and insulin tolerance tests were performed, and body composition was analyzed. Weight gain and glucose levels during adolescence and adulthood were similar in male offspring of diabetic and control pregnancies. Body weight and fat mass after high-fat diet, as well as glucose and insulin tolerance tests, were unaltered between male adult offspring of both groups. Glycemic control consisting of up to 49 000 individual glucose measures was comparable between both groups. Intrauterine exposure to maternal hyperglycemia and hyperinsulinemia without obesity had no impact on male offspring metabolic health in our model. We conclude that the intrauterine exposure itself does not represent a mechanism for fetal programming of diabetes and obesity in our model. Other maternal metabolic parameters during pregnancy, such as obesity, might impact long-term offspring metabolic health.

First Authors:
Till Schütte,Sarah M Kedziora

Correspondence Authors:
Kristin Kräker,Michaela Golic

All Authors:
Till Schütte,Sarah M Kedziora,Nadine Haase,Florian Herse,Andreas Busjahn,Anna Birukov,Natalia Alenina,Dominik N Müller,Michael Bader,Michael Schupp,Ralf Dechend,Kristin Kräker,Michaela Golic

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