显微镜下结肠炎可能是帕金森病的共病,而非其风险因素
创作:szx 审核:szx 04月06日
  • 纳入12609名显微镜下结肠炎(MC)患者及58879名对照,平均随访7年期间,在MC患者及对照中共发生449例帕金森病(PD);
  • 总体上,MC患者的PD风险增加76%(HR=1.76),但该关联随MC确诊时间而减弱;
  • MC确诊2年内及3年内的PD风险均显著升高(分别为对照的3.45倍及1.80倍),但MC确诊5年后的PD风险与对照相比无显著变化;
  • 在6281名MC患者及12351名患者的健康兄弟姐妹中,MC与PD也存在相似关联;
  • MC与已确诊的PD之间也显著相关(OR=3.46)。
主编推荐语
szx
Movement Disorders上发表的一项前瞻性队列研究结果,对超过1.2万名显微镜下结肠炎患者及近6万名对照进行平均7年的随访后发现,显微镜下结肠炎确诊后的3年内,患者的帕金森病风险显著升高,但这种关联在显微镜下结肠炎确诊5年后不再存在。另外,显微镜下结肠炎与已发生的帕金森病之间也存在显著关联。该研究结果提示,显微镜下结肠炎可能不是帕金森病的风险因素,而可能是帕金森病的共病(comorbidity),或在帕金森病发病后开始发展。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
Movement Disorders [IF:8.679]

Association between Microscopic Colitis and Parkinson's Disease in a Swedish Population

瑞典人群中显微镜下结肠炎与帕金森病的关联

10.1002/mds.28594

03-25, Article

Abstract & Authors:展开

Abstract:收起
Background: Gastrointestinal inflammation has been linked with Parkinson's disease (PD). Microscopic colitis (MC) is an intestinal inflammatory disease with unknown relationship with PD.
Objective: This study aimed to examine the association of MC with PD risk.
Methods: In this nationwide matched cohort study in Sweden, PD incidence was compared between 12,609 patients with histologically confirmed MC and a matched population cohort of 58,879 MC‐free individuals and a sibling cohort comprising all unaffected siblings of the MC patients (NMC/NSibling = 6281/12,351). Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models.
Results: During a mean follow‐up of ~7 years, we identified 449 incident PD diagnoses among the MC patients and the population cohort. Overall, MC was associated with an adjusted HR of 1.76 for PD, but the association attenuated substantially during follow‐up. In the time‐varying effects model, PD hazard was 3.45‐fold (95% CI: 2.42, 4.93) higher during the first 2 years after biopsy and 1.80‐fold (95% CI: 1.23, 2.64) higher during the following 3 years among MC versus MC‐free individuals but was not different beyond 5 years after biopsy (HR: 1.03; 95% CI: 0.68, 1.54). This temporal pattern of MC–PD associations persisted when comparing MC patients to their siblings. In a post hoc case–control analysis, we also detected a strong association between MC and preexisting PD (odds ratio: 3.46; 95% CI: 2.91, 4.12).
Conclusions: Our findings suggest that MC may not be a risk factor for PD; instead, it may co‐occur with PD as a comorbidity or develop after a diagnosis of PD. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society

First Authors:
Xiaoying Kang

Correspondence Authors:
Xiaoying Kang

All Authors:
Xiaoying Kang,Alexander Ploner,Bjorn Roelstraete,Hamed Khalili,Dylan M Williams,Nancy L Pedersen,Jonas Ludvigsson,Karin Wirdefeldt

评论