富含低聚果糖的菊粉对乳糜泻患儿体内维生素D/E的影响
创作:szx 审核:szx 2018年12月03日
  • 34名长期进行无谷蛋白饮食的乳糜泻患儿随机分为2组,每日摄入10g富含低聚果糖的菊粉(Synergy 1)或安慰剂,持续干预3个月;
  • 干预结束后,益生元组患儿体内的25(OH)D浓度显著增加(增加了42%),而安慰剂组患儿的这一指标无显著变化,益生元组中有46%的患儿的维生素D状态达到理想水平;
  • 益生元组患儿体内的维生素E浓度显著增加(增加了19%),而安慰剂组患儿的这一指标无显著变化。
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szx
Nutrients上发表的一项最新研究发现,在长期进行无谷蛋白饮食的乳糜泻患儿中,补充益生元(富含低聚果糖的菊粉)可显著改善体内的维生素D及维生素E水平。
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Nutrients [IF:4.546]

Beneficial Effect of Oligofructose-Enriched Inulin on Vitamin D and E Status in Children with Celiac Disease on a Long-Term Gluten-Free Diet: A Preliminary Randomized, Placebo-Controlled Nutritional Intervention Study

富含低聚果糖的菊粉对长期进行无谷蛋白饮食的乳糜泻患儿的维生素D/E状态的有益影响:

10.3390/nu10111768

2018-11-15, Article

Abstract & Authors:展开

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Prebiotics have been shown to improve absorption of some nutrients, including vitamins. This pilot study evaluated the effect of the prebiotic oligofructose-enriched inulin (Synergy 1) on fat-soluble vitamins status, parathormone, and calcium-related elements in pediatric celiac disease (CD) patients ( = 34) on a strict gluten-free diet (GFD). Participants were randomized into a group receiving 10 g of Synergy 1 or placebo (maltodextrin) together with a GFD. At baseline and after 3 months of intervention, 25-hydroxyvitamin D [25(OH)D], parathormone, vitamin E and A, calcium, phosphate, magnesium, total protein, and albumin were determined. Concentration of 25(OH)D increased significantly ( < 0.05) by 42% in CD patients receiving Synergy 1 in GFD, whereas no change was observed in placebo. Vitamin D status reached an optimal level in 46% of patients receiving Synergy 1. No significant difference in parathormone, calcium, and phosphate levels was observed. Concentration of vitamin E increased significantly ( < 0.05) by 19% in patients receiving Synergy 1, but not in the placebo. Vitamin A levels were not changed. Supplementation of GFD with Synergy 1 improved vitamin D and vitamin E status in children and adolescents with CD and could be considered a novel complementary method of management of fat-soluble vitamins deficiency in pediatric CD patients.

First Authors:
Natalia Drabińska

Correspondence Authors:
Urszula Krupa-Kozak

All Authors:
Natalia Drabińska,Urszula Krupa-Kozak,Paweł Abramowicz,Elżbieta Jarocka-Cyrta

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