肠道菌群的季节性变化,或受松果体调控
  • 光周期可调节内源性的松果体褪黑素的夜间分泌,影响肠道菌群组成的季节性变化;
  • 将切除松果体的仓鼠放入长或短的光周期8周,每周收集粪便样本,并测量生理和行为变化(摄食量、睾丸重量和体重);
  • 普氏菌属、乳杆菌属和脱硫弧菌属等受到切除手术和时间的共同影响,多种菌属与饮食、睾丸重量和体重显著相关;
  • 睾丸重量和体重与肠道菌群的整体群落结构有显著的相关性;
  • 松果体介导肠道菌群的季节性变化。
主编推荐语
mildbreeze
西伯利亚仓鼠的生理和行为有季节性变化,松果体分泌的褪黑素在其中发挥重要作用。Journal of Pineal Research近期发表研究表明,松果体可能通过神经内分泌途径,在一定程度上介导了西伯利亚仓鼠的肠道菌群的季节性变化,且一些菌群成员与宿主的生理和行为变化相关。
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A novel role for the pineal gland: Regulating seasonal shifts in the gut microbiota of Siberian hamsters

松果体的一个新作用:调节西伯利亚仓鼠肠道菌群的季节性变化

10.1111/jpi.12696

2020-09-24, Article

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The gut microbiota plays a significant role in a variety of host behavioral and physiological processes. The mechanisms by which the gut microbiota and the host communicate are not fully resolved but include both humoral and direct neural signals. The composition of the microbiota is affected by internal (host) factors, and external (environmental) factors. One such signal is photoperiod, which is represented endogenously by nocturnal pineal melatonin (MEL) secretion. Removal of the MEL signal via pinealectomy abolishes many seasonal responses to photoperiod. In Siberian hamsters (Phodopus sungorus), MEL drives robust seasonal shifts in physiology and behavior, such as immunity, stress, body mass, and aggression. While the profile of the gut microbiota also changes by season, it is unclear whether these changes are driven by pineal signals. We hypothesized that the pineal gland mediates seasonal alterations in the composition of the gut microbiota. To test this, we placed pinealectomized and intact hamsters into long or short photoperiods for 8 weeks, collected weekly fecal samples, and measured weekly food intake, testis volume, and body mass. We determined microbiota composition using 16s rRNA sequencing (Illumina MiSeq). We found significant effects of treatment and time on the abundances of numerous bacterial genera. We also found significant associations between individual OTU abundances and body mass, testis mass, and food intake, respectively. Finally, results indicate a relationship between overall community structure, and body and testis masses. These results firmly establish a role for the pineal gland in mediating seasonal alterations in the gut microbiota. Further, these results identify a novel neuroendocrine pathway by which a host regulates seasonal shifts in gut community composition, and indicates a relationship between seasonal changes in the gut microbiota and seasonal physiological adjustments.

First Authors:
Elyan K Shor

Correspondence Authors:
Elyan K Shor

All Authors:
Elyan K Shor,Shawn P Brown,David A Freeman

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