哪些菌群因素介导了母体对后代体重/过敏的影响?
  • 纳入1667对母婴进行纵向队列研究,分析多种母体因素与幼儿期体重和过敏的关联中的肠道菌群介导作用;
  • 剖宫产和首次妊娠产程过长后,3月龄时肠杆菌科/拟杆菌科(E/B)比值较高是幼儿超重的主要途径,较高的E/B比值和12月龄时的艰难梭菌定植是幼儿期特应性致敏的主要途径;
  • 产程过长后双歧杆菌属不足是超重的次要途径;
  • 受3个月时艰难梭菌定植的影响,代谢物丙酸和甲酸是影响儿童预后的次要途径,甲酸位于多种途径的交叉点。
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mildbreeze
剖宫产等孕产期因素与后代发生超重和过敏性疾病的风险升高相关,Gastroenterology发表的一项新研究,分析了肠道菌群因素在其中的介导作用。通过分析加拿大的1667对母婴样本和数据,该研究表明,婴儿期的肠道菌群群及其代谢物可预测幼儿期的超重和特应性敏感状态,关键的菌群介质包括肠杆菌科/拟杆菌科的比值、艰难梭菌、双歧杆菌属以及若干菌群代谢产物。
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Gastroenterology [IF:17.373]

From birth to overweight and atopic disease: multiple and common pathways of the infant gut microbiome

从出生到超重和特应性疾病:婴儿肠道微生物的多重和共同途径

10.1053/j.gastro.2020.08.053

2020-09-15, Article

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Background and aims: Few studies, even those with cohort designs, test the mediating effects of infant gut microbes and metabolites on the onset of disease. We undertook such a study.
Methods: Using SEM path analysis, we tested directional relationships between first pregnancy, birth mode, prolonged labour and breastfeeding; infant gut microbiota, metabolites and Immunoglobulin A; and childhood BMI and atopy in 1667 infants.
Results: Following both cesarean birth, and prolonged labour with a first pregnancy, a higher Enterobacteriaceae/Bacteroidaceae (E/B) ratio at 3 months was the dominant path to overweight; higher E/B ratios and Clostridiodes difficile colonization at 12 months were the main pathway to atopic sensitization. Depletion of Bifidobacterium following prolonged labour was a secondary pathway to overweight. Influenced by C. difficile colonization at 3 months, metabolites propionate and formate were secondary pathways to child outcomes, with a key finding that formate was at the intersection of several paths.
Conclusion: Pathways from cesarean section and first pregnancy to child overweight and atopy share many common mediators of the infant gut microbiome, notably C. difficile colonization.

First Authors:
Khanh Vu

Correspondence Authors:
Anita L Kozyrskyj

All Authors:
Khanh Vu,Wendy Lou,Hein M Tun,Theodore B Konya,Nadia Morales-Lizcano,Radha S Chari,Catherine J Field,David S Guttman,Rupasri Mandal,David S Wishart,Meghan B Azad,Allan B Becker,Piush J Mandhane,Theo J Moraes,Diana L Lefebvre,Malcolm R Sears,Stuart E Turvey,Padmaja Subbarao,James A Scott,Anita L Kozyrskyj

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