Science子刊:实锤!母乳喂养可以降低母亲未来糖尿病风险
创作:尹小甜 审核:Epi汪 2020年05月22日
  • 纳入85名母乳喂养的母亲和99名非母乳喂养的母亲进行队列观察;
  • 产后2月时,两组女性多项糖耐量指标无统计学差异,而在产后3.6年,母乳组糖耐量明显改善,松田指数和处置指数均更高;
  • 在小鼠模型中,母乳组产后3周至4个月里糖耐量和β细胞功能明显改善;
  • 实验证实,催乳素可诱导β细胞释放5-羟色胺(5-HT),而5-HT分泌进一步刺激β细胞增殖;
  • 另外,5-HT可以作为细胞抗氧化剂,从而改善β细胞的功能。
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本研究通过人群队列数据+动物实验研究证实了母乳喂养可以通过5-羟色胺,提高胰岛β细胞的功能,改善其糖耐量,从而对女性具有长期的健康益处。
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Lactation improves pancreatic β cell mass and function through serotonin production

哺乳通过5-羟色胺生产改善胰岛B细胞质量和功能

10.1126/scitranslmed.aay0455

2020-04-29, Article

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Pregnancy imposes a substantial metabolic burden on women through weight gain and insulin resistance. Lactation reduces the risk of maternal postpartum diabetes, but the mechanisms underlying this benefit are unknown. Here, we identified long-term beneficial effects of lactation on β cell function, which last for years after the cessation of lactation. We analyzed metabolic phenotypes including β cell characteristics in lactating and non-lactating humans and mice. Lactating and non-lactating women showed comparable glucose tolerance at 2 months after delivery, but after a mean of 3.6 years, glucose tolerance in lactated women had improved compared to non-lactated women. In humans, the disposition index, a measure of insulin secretory function of β cells considering the degree of insulin sensitivity, was higher in lactated women at 3.6 years after delivery. In mice, lactation improved glucose tolerance and increased β cell mass at 3 weeks after delivery. Amelioration of glucose tolerance and insulin secretion were maintained up to 4 months after delivery in lactated mice. During lactation, prolactin induced serotonin production in β cells. Secreted serotonin stimulated β cell proliferation through serotonin receptor 2B in an autocrine and paracrine manner. In addition, intracellular serotonin acted as an antioxidant to mitigate oxidative stress and improved β cell survival. Together, our results suggest that serotonin mediates the long-term beneficial effects of lactation on female metabolic health by increasing β cell proliferation and reducing oxidative stress in β cells.

First Authors:
Joon Ho Moon,Hyeongseok Kim

Correspondence Authors:
Michael S German,Hak Chul Jang,Hail Kim

All Authors:
Joon Ho Moon,Hyeongseok Kim,Hyunki Kim,Jungsun Park,Wonsuk Choi,Wongun Choi,Hyun Jung Hong,Hyun-Joo Ro,Sangmi Jun,Sung Hee Choi,Ronadip R Banerjee,Minho Shong,Nam Han Cho,Seung K Kim,Michael S German,Hak Chul Jang,Hail Kim

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