摄入全谷物食品对炎症标志物的影响
创作:兵兵 审核:szx 2019年08月03日
  • 纳入14项RCT研究(1238名受试者)进行荟萃分析;
  • 全谷物膳食并不会显著影响血浆C-反应蛋白(CRP)浓度,但是在高CRP个体以及等热量研究中,其优势明显;
  • 全谷物膳食也没有显著影响血浆IL-6浓度,但显著影响非健康个体的IL-6浓度;
  • 全谷物膳食对TNF-α、纤溶酶原激活物抑制剂-1(PAI-1)无显著影响;
  • 全谷物膳食对TNF-α、PAI-1、CRP、IL-6等血浆炎症因子的浓度无显著影响;
  • 但是,全谷物膳食的优势可以在一些亚组中体现。
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szx
Advances in Nutrition上发表的一项荟萃分析结果,发现全谷物食品的摄入对多数炎症标志物并无显著影响,但在一些亚组分析中表现出一定的益处。
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The Effect of Whole-Grain Intake on Biomarkers of Subclinical Inflammation: A Comprehensive Meta-analysis of Randomized Controlled Trials

全谷物膳食对于亚临床炎症生物标志物的影响:一项对随机对照试验的综合荟萃分析

10.1093/advances/nmz063

2019-07-13, Article

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Findings on the effect of whole-grain consumption on inflammatory biomarkers are conflicting. This study aimed to summarize available studies on the effects of whole-grain consumption on inflammatory biomarkers in adults. Online databases including PubMed, Scopus, ISI Web of Science, and Google Scholar were searched for relevant studies published up to January 2018, using relevant keywords. We included randomized controlled trials (RCTs) investigating the effect of whole-grain foods or diets high in whole-grain foods on markers of inflammation. Studies were selected if they had a control diet low in whole grains or diets without whole grains, whether calorie restricted or not. We did not include studies that examined the effect of individual grain components, including bran or germ, or fiber-based diets. Overall, 14 RCTs, with 1238 individuals aged ≥18 y, were included. Pooling 13 effect sizes from 11 RCTs on serum C-reactive protein (CRP) concentrations, we found no significant effect of whole-grain consumption on serum CRP concentrations [weighted mean difference (WMD): -0.29 mg/L; 95% CI: -1.10, 0.52 mg/L]. However, the beneficial effects of whole-grain intake on serum CRP concentrations were observed in studies in individuals with elevated serum concentrations of CRP and studies with isocaloric diets. Combining 11 effect sizes from 10 RCTs, we found no significant effect of whole-grain consumption on serum IL-6 concentrations (WMD: -0.08 pg/mL; 95% CI: -0.27, 0.11 pg/mL). Nevertheless, we observed a significant effect of whole-grain consumption on serum IL-6 concentrations in studies in unhealthy individuals. A nonsignificant effect of whole-grain intake on circulating serum TNF-α concentrations was also seen when we summarized effect sizes from 7 RCTs (WMD: -0.06 pg/mL; 95% CI: -0.25, 0.14 pg/mL). Such a nonsignificant effect was observed for serum concentrations of plasminogen activator inhibitor-1 (PAI-1) (WMD: -3.59; 95% CI: -1.25, 8.44 kU/L). Unlike observational studies, we found no significant effect of whole-grain consumption on serum concentrations of inflammatory cytokines, including serum concentrations of CRP, IL-6, TNF-α, and PAI-1. However, beneficial effects of whole grains were found in some subgroups. Given the high between-study heterogeneity, deriving firm conclusions is difficult.

First Authors:
Sepideh Rahmani

Correspondence Authors:
Ahmad Esmaillzadeh

All Authors:
Sepideh Rahmani,Omid Sadeghi,Mehdi Sadeghian,Narges Sadeghi,Bagher Larijani,Ahmad Esmaillzadeh

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