薛丽香+徐立+蔡军:肠道菌群与心血管疾病(综述)
创作:EADGBE 审核:EADGBE 10月13日
  • 肠道菌群主要由厚壁菌门、拟杆菌门、放线菌门和变形菌门细菌组成,并处于相对平衡状态;
  • 肠道菌群失衡与动脉粥样硬化、冠状动脉疾病、高血压、心力衰竭和心房颤动等疾病关系密切;
  • 血液菌群失衡可能通过慢性感染和炎症反应导致心血管疾病;
  • 菌群代谢产物如短链脂肪酸、氧化三甲胺、氨基酸代谢产物等参与心血管疾病的发生与发展;
  • 通过饮食干预、抗生素治疗、服用益生菌、粪菌移植、共生菌改造等手段调节肠道菌群可有效改善心血管疾病。
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EADGBE
肠道菌群组成、特异性菌种或菌群的变化与各类疾病的发生有密切的相关性。最近的研究表明,心血管疾病(Cardiovascular disease,CVD)也可能与肠道菌群失衡有关。北京大学第三医院的薛丽香、首都医科大学附属北京朝阳医院的徐立和阜外医院蔡军等人发表在Protein & Cell上的一篇综述文章,系统阐述了肠道菌群失调与高血压、动脉粥样硬化和心力衰竭等CVD的相关性以及对CVD的发生和发展的潜在影响,并指出调控肠道菌群有望作为心血管疾病的潜在治疗新靶点。
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Protein & Cell [IF:10.164]

Gut microbes in cardiovascular diseases and their potential therapeutic applications

肠道微生物与心血管疾病及其潜在的治疗应用

10.1007/s13238-020-00785-9

09-28, Review

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Microbial ecosystem comprises a complex community in which bacteria interact with each other. The potential roles of the intestinal microbiome play in human health have gained considerable attention. The imbalance of gut microbial community has been looked to multiple chronic diseases. Cardiovascular diseases (CVDs) are leading causes of morbidity worldwide and are influenced by genetic and environmental factors. Recent advances have provided scientific evidence that CVD may also be attributed to gut microbiome. In this review, we highlight the complex interplay between microbes, their metabolites, and the potential influence on the generation and development of CVDs. The therapeutic potential of using intestinal microbiomes to treat CVD is also discussed. It is quite possible that gut microbes may be used for clinical treatments of CVD in the near future.

First Authors:
Ling Jin

Correspondence Authors:
Lixiang Xue,Li Xu,Jun Cai

All Authors:
Ling Jin,Xiaoming Shi,Jing Yang,Yangyu Zhao,Lixiang Xue,Li Xu,Jun Cai

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