华中科大:二甲双胍通过调节菌群,改善肥胖小鼠的学习记忆
创作:orchid 审核:szx 03月17日
  • 在高脂饮食诱导的肥胖小鼠中,海马齿状回的神经发生损伤,且学习及记忆功能衰退,而二甲双胍处理可恢复;
  • 二甲双胍可通过改善高脂饮食诱导的肥胖小鼠的肠道菌群组成失调,从而抑制大脑中的小神经胶质细胞活化和神经炎症,并防止海马新生神经元衰退,以改善其学习和记忆能力;
  • 小神经胶质细胞介导了二甲双胍对海马神经发生的促进作用,通过PLX3397去除肥胖小鼠大脑中的小神经胶质细胞后,可显著增加海马中的新生神经元数量。
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来自华中科技大学的颜欢欢团队与裴磊团队在Brain Behavior and Immunity上发表的一项最新研究,发现二甲双胍可通过调节高脂饮食诱导的肥胖小鼠的肠道菌群,以抑制小神经胶质细胞的活化及神经炎症,从而促进海马神经发生并改善学习记忆。
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Metformin restores hippocampal neurogenesis and learning and memory via regulating gut microbiota in the obese mouse model

在肥胖小鼠模型中,二甲双胍通过调节肠道菌群恢复海马神经发生和学习记忆

10.1016/j.bbi.2021.02.011

02-18, Article

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Numerous studies have shown that over-nutritional obesity may lead to pre-diabetes, type 2 diabetes and cognitive decline. As the degree of metabolic disorders increases, the cognitive decline is getting worse. However, the cellular events that cause this cognitive dysfunction is yet to be clarified. We used a high-fat diet (HFD) consumption-induced obesity mouse model to test the effects of metformin on the hippocampal neurogenesis and learning and memory abilities of obese mice. 5-Bromo-2'-deoxyuridine (BrdU) labelling and retrovirus labeling were applied to detect hippocampal newborn neurons. Behavioral experiments were used to detect learning and memory abilities of mice. Bacterial flora sequencing was performed to detect the composition of gut microbiota. The positron emission tomography (PET) was conducted to detect the activity of neuronal nucleus. Our results reveal that metformin restores the impairment of neurogenesis in the dentate gyrus and finally prevents the cognitive decline of the obese mice. Moreover, the therapeutic effects of metformin are achieved by regulating the composition of gut microbiota of mice, which may inhibit microglia activation and neuroinflammation in the brain of obese mice. This study suggests that metformin may be taken as a promising candidate for the intervention of cognitive decline related to imbalance of gut microbiota caused by obesity.

First Authors:
Xiaoyi Ma

Correspondence Authors:
Lei Pei,Huanhuan Yan

All Authors:
Xiaoyi Ma,Wenchang Xiao,Hao Li,Pei Pang,Feixiao Xue,Lu Wan,Lei Pei,Huanhuan Yan

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