母乳功能也有亲疏之分?
创作:Epi汪 审核:Epi汪 2020年09月04日
  • 对于亲生母亲不能提供母乳(OMM)喂养的早产儿,会接受来自母乳捐赠库中巴氏消毒过的母乳(DHM);
  • 比较OMM和DHM中代谢特征改变,发现二者在半乳糖、淀粉和蔗糖代谢途径中存在差异;
  • 接受两种母乳喂养的婴儿尿液中,代谢组分析发现,类固醇激素合成和嘧啶代谢途径发生变化;
  • 分析两组婴儿的肠道菌群组成,发现二者β多样性存在差异,DHM组肠杆菌科相对丰度较低;
  • 母乳中甾体激素对早产儿体内激素合成途径的活性有显著影响。
主编推荐语
Epi汪
哺乳期母亲把婴儿吃不完的母乳捐献,给有需求的婴儿使用。这种母乳库构建设想已经在实践,但是由于各种原因,目前在我国似乎并没有全面铺开。本研究基于此,欲评估经过巴氏消毒的捐赠母乳的“健康效应”, 发现两组母乳对早产儿的代谢组特征的影响确实存在不同。这其中的具体原因,值得仔细推敲。
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Effect of donor human milk on host-gut microbiota and metabolic interactions in preterm infants

捐赠母乳早产儿宿主肠道菌群和代谢的交互作用

10.1016/j.clnu.2020.08.013

2020-08-19, Article

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Background & aims: Human milk is the gold standard for infant nutrition. Preterm infants whose mothers are unable to provide sufficient own mother's milk (OMM), receive pasteurized donor human milk (DHM). We studied metabolic signatures of OMM and DHM and their effect on the interplay of the developing microbiota and infant's metabolism.
Methods: Metabolic fingerprinting of OMM and DHM as well as infant's urine was performed using liquid chromatography-mass spectrometry and the infant's stool microbiota was analyzed by 16S rRNA sequencing.
Results: Significant differences in the galactose and starch and sucrose metabolism pathways when comparing OMM and DHM, and alterations of the steroid hormone synthesis and pyrimidine metabolism pathways in urine were observed depending on the type of feeding. Differences in the gut-microbiota composition were also identified.
Conclusion: The composition of DHM differs from OMM and feeding of DHM has a significant impact on the metabolic phenotype and microbiota of preterm infants. Our data help to understand the origin of the observed changes generating new hypothesis: i) steroid hormones present in HM have a significant influence in the activity of the steroid hormone biosynthesis pathway in preterm infants; ii) the pyrimidine metabolism is modulated in preterm infants by the activity of gut-microbiota. Short- and long-term implications of the observed changes for preterm infants need to be assessed in further studies.

First Authors:
Jose David Pi  neiro-Ramos

Correspondence Authors:
Julia Kuligowski

All Authors:
Jose David Pi  neiro-Ramos,Anna Parra-Llorca,Isabel Ten-Domenech ,María Gormaz,Amparo Ramon-Beltr,María Cernada,Guillermo Quintas ,María Carmen Collado,Julia Kuligowski,Maximo Vento

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