Nature子刊:肠道菌群如何调节宿主代谢和能量稳态(综述)
创作:Sophia 审核:mildbreeze 2019年04月01日
  • 肠道菌群组成及其代谢/衍生物影响宿主能量稳态;
  • 短链脂肪酸(SCFA)可作为能量来源并参与脂肪生成和糖异生等代谢途径,还能刺激生成胃肠激素,与ClpB等菌群组分和菌群调控的神经递质一起经肠脑轴影响进食;
  • 胆汁酸、SCFA、内源性大麻素等可调节产热和脂肪褐化,冷暴露、抗生素和运动等因素可经菌群影响能量代谢;
  • 支链氨基酸相关代谢物、吲哚丙酸等色氨酸衍生物、氧化三甲胺等也参与代谢调节;
  • 基于肠道菌群的疗法有望改善代谢健康。
主编推荐语
mildbreeze
肠道菌群对宿主代谢的影响,是菌群研究的一大热点。《Nature Metabolism》近期发表综述,回顾了近15年来该领域的主要进展,介绍了肠道菌群组成及其代谢物和衍生物对宿主代谢稳态的调控机制和与代谢疾病的关联,以及多种内源和外源因素如何作用于菌群进而影响能量平衡。虽然很可能只是揭开了冰山一角,但这些发现无疑为基于肠道菌群治疗代谢疾病的疗法,奠定了一定的理论基础。
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Microbial regulation of organismal energy homeostasis

机体能量平衡的微生物调节

10.1038/s42255-018-0017-4

2019-01-07, Review

Abstract & Authors:展开

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The gut microbiome has emerged as a key regulator of host metabolism. Here we review the various mechanisms through which the gut microbiome influences the energy metabolism of its host, highlighting the complex interactions between gut microbes, their metabolites and host cells. Among the most important bacterial metabolites are short-chain fatty acids, which serve as a direct energy source for host cells, stimulate the production of gut hormones and act in the brain to regulate food intake. Other microbial metabolites affect systemic energy expenditure by influencing thermogenesis and adipose tissue browning. Both direct and indirect mechanisms of action are known for specific metabolites, such as bile acids, branched chain amino acids, indole propionic acid and endocannabinoids. We also discuss the roles of specific bacteria in the production of specific metabolites and explore how external factors, such as antibiotics and exercise, affect the microbiome and thereby energy homeostasis. Collectively, we present a large body of evidence supporting the concept that gut microbiota-based therapies can be used to modulate host metabolism, and we expect to see such approaches moving from bench to bedside in the near future.

First Authors:
Patrice D Cani

Correspondence Authors:
Patrice D Cani

All Authors:
Patrice D Cani,Matthias Van Hul,Charlotte Lefort,Clara Depommier,Marialetizia Rastelli,Amandine Everard

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