一文+一图读懂:肠道菌群在人体代谢健康中的重要作用(重磅综述)
创作:orchid 审核:mildbreeze 2020年10月01日
  • 肠道菌群可影响人体代谢健康,饮食对二者有调控作用;
  • 菌群异常(如多样性降低、特定成员和功能改变等)可能参与了肥胖、2型糖尿病、代谢性肝病、心血管代谢疾病和营养不良等代谢疾病的发生发展;
  • 短链脂肪酸、脂多糖、次级胆汁酸、三甲胺、咪唑丙酸、支链氨基酸、吲哚及其衍生物等一系列的菌群代谢产物和衍生物,可作为菌群的“信使”,影响宿主能量稳态、肥胖、食欲、血糖调控、胰岛素敏感性、炎症和内分泌调节等,调控宿主代谢。
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Nature Reviews Microbiology近期发表了来自丹麦哥本哈根大学Oluf Pedersen团队的一篇重磅综述,总结了与多种常见代谢疾病相关的肠道菌群变化特征,以及菌群代谢和衍生物参与驱动疾病发生发展的可能机制,并探讨了以菌群为导向的干预方法和未来的研究转化方向等内容。我们特别将文章中的图片编译为一图读懂,希望能帮助你涨知识。
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Gut microbiota in human metabolic health and disease

肠道菌群在人体代谢健康和疾病中的作用

10.1038/s41579-020-0433-9

2020-09-04, Review

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Observational findings achieved during the past two decades suggest that the intestinal microbiota may contribute to the metabolic health of the human host and, when aberrant, to the pathogenesis of various common metabolic disorders including obesity, type 2 diabetes, non-alcoholic liver disease, cardio-metabolic diseases and malnutrition. However, to gain a mechanistic understanding of how the gut microbiota affects host metabolism, research is moving from descriptive microbiota census analyses to cause-and-effect studies. Joint analyses of high-throughput human multi-omics data, including metagenomics and metabolomics data, together with measures of host physiology and mechanistic experiments in humans, animals and cells hold potential as initial steps in the identification of potential molecular mechanisms behind reported associations. In this Review, we discuss the current knowledge on how gut microbiota and derived microbial compounds may link to metabolism of the healthy host or to the pathogenesis of common metabolic diseases. We highlight examples of microbiota-targeted interventions aiming to optimize metabolic health, and we provide perspectives for future basic and translational investigations within the nascent and promising research field.

First Authors:
Yong Fan

Correspondence Authors:
Oluf Pedersen

All Authors:
Yong Fan,Oluf Pedersen

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宏基因组微信公众号

Nature综述:肠道微生物在人类代谢健康与疾病中的作用

范勇,2020-09-17

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