被神化的DHA,孕期需不需要补充?
创作:Epi汪 审核:Epi汪 2020年09月18日
  • 检索筛选相关文献,最终纳入11项RCT研究,旨在探索孕期和/或哺乳期母亲补充鱼油对出生体重及神经系统发育的影响;
  • 总体上看,干预组儿童在注意力、神经运动技能、智力、语言、执行能力和短期记忆等6个方面均与对照组无统计学差异;
  • 干预组婴儿的平均出生体重有增高的趋势,但是差异无统计学意义;
  • 未来的研究设计应着重解决样本量低、儿童神经发育评估不准确、血液ω–3脂肪酸评估不准确、基因和环境交互作用等问题。
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Epi汪
二十二碳六烯酸(DHA)和二十碳五烯酸(EPA)被证明是大脑和神经发育的必须营养素,因而被推上了保健品的“神坛”。但是诸多临床随机对照试验发现,孕期母亲补充DHA并不能提升后代儿童的神经发育水平。本荟萃分析综合了多项RCT研究证据,同时也指出未来该领域的研究应该着重解决的问题。
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Impact of omega-3 fatty acid DHA and EPA supplementation in pregnant or breast-feeding women on cognitive performance of children: systematic review and meta-analysis

孕期和哺乳期ω–3脂肪酸DHA和EPA补充对儿童神经发育的影响:系统综述和荟萃分析

10.1093/nutrit/nuaa060

2020-09-11, Article

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Introduction: The omega-3 long-chain polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are important for brain development and cognitive performance. Because they are semi-essential fatty acids, they must be obtained from food. However, the dietary reference intakes of DHA and EPA have not yet been established. In women, a low DHA and/or EPA serum level during pregnancy or breastfeeding might negatively affect their children. For this study, we conducted a systematic review and meta-analysis of randomized control trials on the association between the consumption of fish oil supplements in pregnant and/or breastfeeding women and the cognitive performance of their children.
Methods: The PubMed, Embase, and Central literature databases were systematically searched. We included and extracted relevant studies in duplicate and assessed study quality. Cognitive outcomes were grouped according to published criteria and according to time elapsed after the intervention. We performed fixed-effects meta-analyses for each cognitive outcome and for birth weight. We assessed potential confounding with meta-regressions and sensitivity analyses.
Results: A total of 11 trials were included. No significant association was found between DHA/EPA supplementation and any of the assessed cognitive parameters or birth weight.
Discussion: Our results confirm previous reviews on the studied topic. Reasons for inconclusive results may be small sample sizes for each assessed category, questionable quality of included studies, and the difficulty of reliably measuring cognitive performance in small children. Blood levels of omega-3 long-chain polyunsaturated fatty acids were mostly not comparable. Furthermore, the influence of genetic and environmental factors could not be assessed. Studies in this field should address such shortcomings.

First Authors:
A Lehner

Correspondence Authors:
N Bender

All Authors:
A Lehner,K Staub,L Aldakak,P Eppenberger,F Ru¨hli,Robert D Martin,N Bender

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