• 肠道菌群与健康的关系密切,失衡的肠道菌群可能是促进各种现代疾病的重要原因之一;
  • 益生元、益生菌、药物、粪菌移植等操纵肠道菌群的方法,已经在治疗类似艰难梭菌感染的疾病中发挥作用;
  • 但尽管前景广阔,通过微生物干预改变肠道菌群结构的概念和方法都还处于起步阶段;
  • 深入研究如何去除有害个体,而让有益微生物茁壮成长是未来基于菌群调节的疗法的必经之路。
蓝灿辉 | 热心肠先生
Engineering [IF:6.495]

Modulation of Gut Microbiota in Pathological States



2017-02-21, Review

Abstract & Authors:展开

The human microbiota is an aggregate of microorganisms residing in the human body, mostly in the gastrointestinal tract (GIT). Our gut microbiota evolves with us and plays a pivotal role in human health and disease. In recent years, the microbiota has gained increasing attention due to its impact on host metabolism, physiology, and immune system development, but also because the perturbation of the microbiota may result in a number of diseases. The gut microbiota may be linked to malignancies such as gastric cancer and colorectal cancer. It may also be linked to disorders such as nonalcoholic fatty liver disease (NAFLD); obesity and diabetes, which are characterized as “lifestyle diseases” of the industrialized world; coronary heart disease; and neurological disorders. Although the revolution in molecular technologies has provided us with the necessary tools to study the gut microbiota more accurately, we need to elucidate the relationships between the gut microbiota and several human pathologies more precisely, as understanding the impact that the microbiota plays in various diseases is fundamental for the development of novel therapeutic strategies. Therefore, the aim of this review is to provide the reader with an updated overview of the importance of the gut microbiota for human health and the potential to manipulate gut microbial composition for purposes such as the treatment of antibiotic-resistant Clostridium difficile (C. difficile) infections. The concept of altering the gut community by microbial intervention in an effort to improve health is currently in its infancy. However, the therapeutic implications appear to be very great. Thus, the removal of harmful organisms and the enrichment of beneficial microbes may protect our health, and such efforts will pave the way for the development of more rational treatment options in the future.

First Authors:
Yulan Wang

Correspondence Authors:
Yulan Wang

All Authors:
Yulan Wang , Baohong Wang , Junfang Wu , Xiangyang Jiang , Huiru Tang , Ole H Nielsen