张和平+杨瑞馥团队:破解保加利亚乳杆菌的基因秘密
  • 保加利亚乳酸杆菌是发酵乳制品中常用菌株;
  • 基于8个保守基因分析蒙古、俄罗斯及中国西部的天然发酵制品中的298株菌株;
  • 251个确认的菌株拥有106个独特的序列类型,可被分为5个地理分布不平均的clonal complex;
  • 种群结构分析显示6个linegae。
#杨瑞馥团队研究论文集# #张和平团队研究论文集#
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Scientific Reports [IF:3.998]

Genetic diversity and population structure of Lactobacillus delbrueckii subspecies bulgaricus isolated from naturally fermented dairy foods

天然发酵乳制品中分离的保加利亚乳酸杆菌的基因多样性及种群结构

10.1038/srep22704

2016-03-04, Article

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Lactobacillus delbrueckii subsp. bulgaricus is one of the most widely used starter culture strains in industrial fermented dairy manufacture. It is also common in naturally fermented dairy foods made using traditional methods. The subsp. bulgaricus strains found in naturally fermented foods may be useful for improving current industrial starter cultures; however, little is known regarding its genetic diversity and population structure. Here, a collection of 298 L. delbrueckii strains from naturally fermented products in Mongolia, Russia, and West China was analyzed by multi-locus sequence typing based on eight conserved genes. The 251 confirmed subsp. bulgaricus strains produced 106 unique sequence types, the majority of which were assigned to five clonal complexes (CCs). The geographical distribution of CCs was uneven, with CC1 dominated by Mongolian and Russian isolates, and CC2-CC5 isolates exclusively from Xinjiang, China. Population structure analysis suggested six lineages, L1-L6, with various homologous recombination rates. Although L2-L5 were mainly restricted within specific regions, strains belonging to L1 and L6 were observed in diverse regions, suggesting historical transmission events. These results greatly enhance our knowledge of the population diversity of subsp. bulgaricus strains, and suggest that strains from CC1 and L4 may be useful as starter strains in industrial fermentation.

First Authors:
Yuqin Song,Zhihong Sun

Correspondence Authors:
Heping Zhang

All Authors:
Yuqin Song,Zhihong Sun,Chenyi Guo,Yarong Wu,Wenjun Liu,Jie Yu,Bilige Menghe,Ruifu Yang,Heping Zhang

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