创作:szx 审核:szx 2018年01月10日
  • 超重及肥胖者的血糖控制、脂质、炎症标记物均显著改变,黑棘皮症(AN)患者的代谢状态更差,且肠道菌群多样性降低;
  • 肥胖患者与健康人的肠道菌群完全不同,肥胖者体内的有益细菌(包括拟杆菌属、产丁酸盐疣微菌科)显著减少,芽孢杆菌属、条件致病菌(包括梭杆菌属埃希氏杆菌属-志贺氏菌属)显著增加;
  • 脂多糖生物合成蛋白、细菌入侵上皮细胞的相关基因上调,葡萄糖、氨基酸相关基因下调。
蓝灿辉 | 热心肠先生
Obesity [IF:3.742]

Dysbiosis Signatures of Gut Microbiota Along the Sequence from Healthy, Young Patients to Those with Overweight and Obesity



2017-12-27, Article

Abstract & Authors:展开

OBJECTIVE: To investigate the gut microbiota in healthy volunteers (HVs), patients with overweight (OW), and patients with obesity (OB), including those with acanthosis nigricans (AN) or without AN (N-AN).
METHODS: Microbial 16S rRNA genes were examined by using pyrosequencing technology and analyzed by using bioinformatics methods.
RESULTS: Subjects in the OW and OB groups showed severe disturbances in glycemic control, lipid profile, and inflammatory markers (all P < 0.05); patients with AN had worse metabolic status (P < 0.001) and a lower diversity of microbiota (P < 0.05). The OB and HV groups showed totally different gut microbiota composition. In the OB group, beneficial microbiotas including Bifidobacterium (0.01% vs. 0.05%, false discovery rate [FDR] = 4.27*10-5 ), anti-inflammatory Faecalibacterium (6.70% vs. 13.82%, FDR = 0.010), and butyrate-producing Ruminococcaceae were significantly decreased, whereas Bacillus (0.58% vs. 0.04%, FDR = 0.013) and potential opportunistic pathogens such as Fusobacterium (1.44% vs. 0.11%, FDR < 0.01) and Escherichia-Shigella (6.01% vs. 0.76%, FDR = 0.041) had outgrown dramatically. Function prediction revealed a significant increase in lipopolysaccharide biosynthesis proteins and bacterial invasion of epithelial cell-associated genes and a significant decrease in glucose and essential amino acid-related genes.
CONCLUSIONS: Gut microbiotas and their functions were significantly changed in obesity. More prospective studies on association and causality between microbiota and obesity are imperative and might contribute to the prevention, diagnosis, and treatment of obesity.

First Authors:
Renyuan Gao,Cuiling Zhu,Hao Li

Correspondence Authors:
Shen Qu,Huanlong Qin

All Authors:
Renyuan Gao,Cuiling Zhu,Hao Li,Mingming Yin,Cheng Pan,Linsheng Huang,Cheng Kong,Xingchun Wang,Yi Zhang,Shen Qu,Huanlong Qin