早饭前锻炼比早饭后锻炼更好
创作:兵兵 审核:兵兵 2019年12月07日
  • 研究纳入超重/肥胖的男性人群,分别采用急性随机交叉设计与慢性(6周)随机对照实验方法;
  • 急性实验中,相对于早饭后锻炼,早饭前锻炼可以增加I型和II型纤维的净肌内脂质利用;
  • 慢性实验中,摄食碳水化合物前后进行锻炼,其对餐后血糖的影响不大;但摄食碳水化合物前锻炼,可以降低餐后胰岛素血症;
  • 上述结果可以导致口服葡萄糖胰岛素敏感性增加,进而提高锻炼期间的脂质代谢;
  • 餐前的规律锻炼也可以增强骨骼肌磷脂和GLUT4蛋白的重组。
主编推荐语
兵兵
本研究分别采用急性和慢性(训练法)两个方案,研究进食前后,人体内的血糖和脂质代谢情况。研究结果表明,进食前进行锻炼,由于体内胰岛素水平较低,机体倾向于调动脂质代谢。虽然餐前锻炼(6周)并没有明显的减肥效果,但可以增加机体对胰岛素的敏感性等,有利于机体健康。
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Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese

不同程度的超重或肥胖男性人群中,不同营养-锻炼时机的胰岛素敏感度与其脂质代谢有关

10.1210/clinem/dgz104

2019-10-19, Article

Abstract & Authors:展开

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Context: Pre-exercise nutrient availability alters acute metabolic responses to exercise, which could modulate training responsiveness.
Objective: To assess acute and chronic effects of exercise performed before versus after nutrient ingestion on whole-body and intramuscular lipid utilization, and postprandial glucose metabolism.
Design: 1) Acute, randomised, crossover design (Acute Study); 2) 6-week, randomised, controlled design (Training Study).
Setting: General community.
Participants: Men with overweight/obesity (mean±SD, BMI: 30.2±3.5 kg.m-2 for Acute Study, 30.9±4.5 kg.m-2 for Training Study).
Interventions: Moderate-intensity cycling performed before versus after mixed-macronutrient breakfast (Acute Study) or carbohydrate (Training Study) ingestion.
Results: Acute Study - exercise before versus after breakfast consumption increased net intramuscular lipid utilization in type I (net change: -3.44±2.63% versus 1.44±4.18% area lipid staining, p < 0.01) and type II fibres (-1.89±2.48% versus 1.83±1.92% area lipid staining, p < 0.05). Training Study - postprandial glycemia was not differentially affected by 6-weeks of exercise training performed before versus after carbohydrate intake (p>0.05). However, postprandial insulinemia was reduced with exercise training performed before, but not after carbohydrate ingestion (p=0.03). This resulted in increased oral glucose insulin sensitivity (25±38 vs -21±32 mL.min-1.m-2; p=0.01), associated with increased lipid utilization during exercise (r=0.50, p=0.02). Regular exercise before nutrient provision also augmented remodelling of skeletal muscle phospholipids and protein content of the glucose transport protein GLUT4 (p<0.05).
Conclusions: Experiments investigating exercise training and metabolic health should consider nutrient-exercise timing, and exercise performed before versus after nutrient intake (i.e., in the fasted state) may exert beneficial effects on lipid utilisation and reduce postprandial insulinemia.

First Authors:
R M Edinburgh

Correspondence Authors:
J T Gonzalez

All Authors:
R M Edinburgh,H E Bradley,N-F Abdullah,S L Robinson,O J Chrzanowski-Smith,J -P Walhin,S Joanisse,K N Manolopoulos,A Philp,A Hengist,A Chabowski,F M Brodsky,F Koumanov,J A Betts,D Thompson,G A Wallis,J T Gonzalez

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