Nature Reviews:一文+一图读懂IBD中的宿主-菌群互作(综述)
创作:szx 审核:szx 02月12日
  • 肠道粘膜屏障将共生菌群与肠道上皮分隔,粘膜处的免疫细胞抑制共生菌群的积累及易位;
  • 一些IBD相关基因突变可导致粘膜屏障或免疫应答受损,引起肠道菌群及免疫平衡的失调;
  • 共生菌群可帮助宿主维持肠道免疫平衡,如分节丝状菌通过促进Th17细胞分化、ILC3活化等增强粘膜免疫应答;
  • 共生菌群在Treg的诱导中发挥重要作用以调控肠道免疫稳态;
  • IBD发病伴随致病菌的积累与易位,IBD进展伴随菌群多样性的降低、有益菌的减少及致病菌的扩增。
#一张图读懂系列文献#
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szx
Nature Reviews Immunology上发表的一篇综述文章,详细介绍了在炎症性肠病(IBD)的发病及进展过程中,粘膜屏障功能及菌群-宿主互作平衡(尤其是菌群-免疫互作)如何被破坏,而导致肠道菌群失调及肠道免疫应答失衡的机制。我们特别将文中的配图改制为一图读懂,希望能帮助专业人士更好的了解文章中的精华内容。
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Host – microbiota interactions in inflammatory bowel disease

IBD中的宿主-菌群互作

10.1038/s41577-019-0268-7

01-31, Review

Abstract & Authors:展开

Abstract:收起
The mammalian intestine is colonized by trillions of microorganisms that have co-evolved with the host in a symbiotic relationship. The presence of large numbers of symbionts near the epithelial surface of the intestine poses an enormous challenge to the host because it must avoid the activation of harmful inflammatory responses to the microorganisms while preserving its ability to mount robust immune responses to invading pathogens. In patients with inflammatory bowel disease, there is a breakdown of the multiple strategies that the immune system has evolved to promote the separation between symbiotic microorganisms and the intestinal epithelium and the effective killing of penetrant microorganisms, while suppressing the activation of inappropriate T cell responses to resident microorganisms. Understanding the complex interactions between intestinal microorganisms and the host may provide crucial insight into the pathogenesis of inflammatory bowel disease as well as new avenues to prevent and treat the disease.

First Authors:
Roberta Caruso,Bernard C Lo

Correspondence Authors:
Gabriel Núñez

All Authors:
Roberta Caruso,Bernard C Lo,Gabriel Núñez

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