Cell子刊:缺少膳食纤维不利于抗生素治疗后的肠道菌群恢复
  • 以移植人类肠道菌群的小鼠为模型,探究饮食、抗生素类型及环境因素,对抗生素后菌群恢复模式的影响;
  • 抗生素使用后菌群能快速复原,伴随短暂的拟杆菌属优势性及不同细菌的差异化多样性降低,并增强菌群对再次抗生素使用的恢复性;
  • 来自人类的菌群比小鼠自身的菌群,有更强的恢复性;
  • 低纤维饮食会加重菌群失衡,严重影响菌群恢复;
  • 单独饲养也影响菌群恢复,而共饲养导致的宿主间传播可增强菌群的复原力,提示环境“细菌库”的重要性。
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mildbreeze
饮食和环境卫生因素如何抗生素干预后的肠道菌群恢复?Cell Host and Microbe近期发表的一项小鼠研究,对抗生素后的肠道菌群恢复进行了系统化的分析,表明低纤维饮食和过于干净的环境(单独饲养)不利于菌群复原,相关发现对于减少抗生素治疗引起的菌群失衡有参考意义。
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Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs

抗生素治疗后肠道菌群的恢复,取决于宿主饮食、社区环境和环境储存库

10.1016/j.chom.2019.10.011

2019-11-13, Article

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Antibiotics alter microbiota composition and increase infection susceptibility. However, the generalizable effects of antibiotics on and the contribution of environmental variables to gut commensals remain unclear. To address this, we tracked microbiota dynamics with high temporal and taxonomic resolution during antibiotic treatment in a controlled murine system by isolating variables such as diet, treatment history, and housing co-inhabitants. Human microbiotas were remarkably resilient and recovered during antibiotic treatment, with transient dominance of resistant Bacteroides and taxa-asymmetric diversity reduction. In certain cases, in vitro sensitivities were not predictive of in vivo responses, underscoring the significance of host and community context. A fiber-deficient diet exacerbated microbiota collapse and delayed recovery. Species replacement through cross housing after ciprofloxacin treatment established resilience to a second treatment. Single housing drastically disrupted recovery, highlighting the importance of environmental reservoirs. Our findings highlight deterministic microbiota adaptations to perturbations and the translational potential for modulating diet, sanitation, and microbiota composition during antibiotics.

First Authors:
Katharine Michelle Ng

Correspondence Authors:
Kerwyn Casey Huang

All Authors:
Katharine Michelle Ng,Andrés Aranda-Díaz,Carolina Tropini,Matthew Ryan Frankel,Willian Van Treuren,Colleen T O'Laughlin,Bryan Douglas Merrill,Feiqiao Brian Yu,Kali M Pruss,Rita Almeida Oliveira,Steven Kyle Higginbottom,Norma F Neff,Michael Andrew Fischbach,Karina Bivar Xavier,Justin Laine Sonnenburg,Kerwyn Casey Huang

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Cell Host and Microbe期刊

Determinants of Microbial Antibiotic Susceptibility: The Commensal Gut Microbiota Perspective

Jacob E. Moskowitz, Suzanne Devkota,2019-11-13

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Nature期刊

The meal plan that hinders the gut’s recovery from antibiotics

2019-11-13

点评:Nature发表的解读短文。

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