港中大团队:我国南方人肠道菌群中常见多种梭杆菌,或与大肠癌有关
创作:FU 审核:mildbreeze 03月01日
  • 分析全球16个人群的3157个肠道宏基因组,研究梭杆菌属的分布情况及其潜在的结直肠癌(CRC)相关基因组特征;
  • 不论是否患有CRC,中国南方人群中多个已知和未知的梭杆菌类群的普遍性、相对丰度和多样性,都高于其它地区人群;
  • 除了具核梭杆菌,可变梭杆菌等梭杆菌类群也在CRC中富集;
  • 在可变梭杆菌和溃疡梭杆菌等细菌类群中,均能检测到与CRC相关的FadA黏附素的同系物,且在CRC人群中含量丰富,但是否会增加CRC风险还需进一步研究。
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mildbreeze
梭杆菌属中,具核梭杆菌在结直肠癌(CRC)中富集,FadA黏附素可能介导了这种细菌对CRC的促进作用。Gut近期发表的来自香港中文大学团队的研究发现,我国南方人群的肠道菌群中,多个梭杆菌属细菌类群都比在其它人群中更为常见,含量和多样性也更高,并且从可变梭杆菌(F. varium)和溃疡梭杆菌(F. ulcerans)等多个梭杆菌菌种中,鉴定出FadA同系物的存在,或许与CRC相关。这些发现不仅扩充了与CRC有潜在关联的肠道细菌种类,也揭示出不同人群中梭杆菌属细菌的分布和多样性差异,再次提示基于菌群类群特征的诊断和治疗方法需要针对不同人群进行“量身定制”。
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Gut [IF:19.819]

Southern Chinese populations harbour non-nucleatum Fusobacteria possessing homologues of the colorectal cancer-associated FadA virulence factor

中国南方人群携带的非具核梭杆菌,含有与结直肠癌相关的FadA黏附素致病因子的同系物

10.1136/gutjnl-2019-319635

02-12, Article

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Objective: Fusobacteria are not common nor relatively abundant in non-colorectal cancer (CRC) populations, however, we identified multiple Fusobacterium taxa nearly absent in western and rural populations to be comparatively more prevalent and relatively abundant in southern Chinese populations. We investigated whether these represented known or novel lineages in the Fusobacterium genus, and assessed their genomes for features implicated in development of cancer.
Methods : Prevalence and relative abundances of fusobacterial species were calculated from 3157 CRC and non-CRC gut metagenomes representing 16 populations from various biogeographies. Microbial genomes were assembled and compared with existing reference genomes to assess novel fusobacterial diversity. Phylogenetic distribution of virulence genes implicated in CRC was investigated.
Results: Irrespective of CRC disease status, southern Chinese populations harboured increased prevalence (maximum 39% vs 7%) and relative abundances (average 0.4% vs 0.04% of gut community) of multiple recognised and novel fusobacterial taxa phylogenetically distinct from Fusobacterium nucleatum. Genomes assembled from southern Chinese gut metagenomes increased existing fusobacterial diversity by 14.3%. Homologues of the FadA adhesin linked to CRC were consistently detected in several monophyletic lineages sister to and inclusive of F. varium and F. ulcerans, but not F. mortiferum. We also detected increased prevalence and relative abundances of F. varium in CRC compared with non-CRC cohorts, which together with distribution of FadA homologues supports a possible association with gut disease.
Conclusion : The proportion of fusobacteria in guts of southern Chinese populations are higher compared with several western and rural populations in line with the notion of environment/biogeography driving human gut microbiome composition. Several non-nucleatum taxa possess FadA homologues and were enriched in CRC cohorts; whether this imposes a risk in developing CRC and other gut diseases deserves further investigation.

First Authors:
Yun Kit Yeoh

Correspondence Authors:
Paul K S Chan

All Authors:
Yun Kit Yeoh,Zigui Chen,Martin C S Wong,Mamie Hui,Jun Yu,Siew C Ng,Joseph J Y Sung,Francis K L Chan,Paul K S Chan

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