四川农业大学:甜菜碱通过肠道菌群改善肥胖和代谢
创作:楸楸 审核:兵兵 02月28日
  • 补充甜菜碱可改善高脂饮食(HFD)诱导的小鼠肠道菌群失调、增加抗肥胖菌株,如艾克曼菌、乳杆菌和双歧杆菌;
  • 甜菜碱通过艾克曼菌改善菌群生态,增加产短链脂肪酸(SCFA)细菌,显著提高乙酸和丁酸水平,进而调节宿主miR-378a启动子的DNA甲基化水平;
  • miR-378a抑制其靶基因Yin yang(YY1)的表达,从而改善小鼠代谢;
  • 补充甜菜碱后,菌群产生的乙酸和丁酸盐对miR-378a-YY1通路的调控是改善肥胖和代谢综合征的关键机制。
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兵兵
四川农业大学朱砺等人发表在Gut Microbes上的文章。研究发现补充甜菜碱可以改善高脂饮食(HFD)诱导的肠道菌群失调,促进艾克曼菌(AKK菌)等增殖。AKK菌等可以产生SCFA,其中乙酸和丁酸可以调节宿主miR-378a-YY1通路,进而改善HFD引起的肥胖和代谢综合征。
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Gut Microbes [IF:7.74]

Dietary betaine prevents obesity through gut microbiota-drived microRNA-378a family

饮食甜菜碱通过肠道菌群驱动的microRNA-378a家族预防肥胖

10.1080/19490976.2020.1862612

02-08, Article

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Betaine is a natural compound present in commonly consumed foods and may have a potential role in the regulation of glucose and lipids metabolism. However, the underlying molecular mechanism of its action remains largely unknown. Here, we show that supplementation with betaine contributes to improved high-fat diet (HFD)-induced gut microbiota dysbiosis and increases anti-obesity strains such as Akkermansia muciniphila, Lactobacillus, and Bifidobacterium. In mice lacking gut microbiota, the functional role of betaine in preventing HFD-induced obesity, metabolic syndrome, and inactivation of brown adipose tissues are significantly reduced. Akkermansia muciniphila is an important regulator of betaine in improving microbiome ecology and increasing strains that produce short-chain fatty acids (SCFAs). Increasing two main members of SCFAs including acetate and butyrate can significantly regulate the levels of DNA methylation at host miR-378a promoter, thus preventing the development of obesity and glucose intolerance. However, these beneficial effects are partially abolished by Yin yang (YY1), a common target gene of the miR-378a family. Taken together, our findings demonstrate that betaine can improve obesity and associated MS via the gut microbiota-derived miR-378a/YY1 regulatory axis, and reveal a novel mechanism by which gut microbiota improve host health.

First Authors:
Jingjing Du,Peiwen Zhang,Jiang Luo,Linyuan Shen

Correspondence Authors:
Bo Zeng,De Wu,Xuewei Li,Li Zhu

All Authors:
Jingjing Du,Peiwen Zhang,Jiang Luo,Linyuan Shen,Shunhua Zhang,Hao Gu,Jin He,Linghui Wang,Xue Zhao,Mailing Gan,Liu Yang,Lili Niu,Ye Zhao,Qianzi Tang,Guoqing Tang,Dongmei Jiang,Yanzhi Jiang,Mingzhou Li,Anan Jiang,Long Jin,Jideng Ma,Surong Shuai,Lin Bai,Jinyong Wang,Bo Zeng,De Wu,Xuewei Li,Li Zhu

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