围产期母鼠摄入低聚半乳糖可影响后代大脑和行为
  • 研究在产前和哺乳期给母鼠补充Bimuno®低聚半乳糖(B-GOS)对后代的大脑和行为的影响;
  • 母鼠补充B-GOS可以增加断奶小鼠的探索行为并降低海马谷氨酸受体基因的表达;
  • 产后补充B-GOS(而非产前)改变后代肠道代谢特征,增加粪便丁酸和丙酸水平;
  • 在成年的后代小鼠中,围产期母体B-GOS摄入增加了雌性后代的皮质谷氨酸受体亚单位和社会偏好,并减轻了焦虑;
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mildbreeze
Brain Behavior and Immunity近期发表的一项小鼠研究表明,围产期母体补充低聚半乳糖,或能对后代的大脑基因表达和行为产生有益影响。
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Mom’s diet matters: Maternal prebiotic intake in mice reduces anxiety and alters brain gene expression and the fecal microbiome in offspring

妈妈的饮食很重要:母鼠摄入益生元可减轻后代的焦虑并改变大脑基因表达和粪便微生物组

10.1016/j.bbi.2020.09.034

2020-10-05, Article

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Compelling evidence links enteric microbes to brain function and behavior. Galacto-oligosaccharide prebiotics have been shown to modulate the composition of gut flora and induce metabolic, neurochemical, and behavioral changes in adult rodents. Despite the brain being most susceptible to environmental factors, such as nutrients and toxins, during the earliest stages of development, it is unknown whether maternal prebiotic supplementation during gestation and lactation influences the offspring gut microbiome, brain, or behavior. The aim of this study was to test whether maternal galacto-oligosaccharide intake during pregnancy and lactation alters the brain and behavior in naïve and endotoxin-challenged offspring. CD1 female mice received either normal drinking water or water supplemented with Bimuno® galacto-oligosaccharides (B-GOS) during gestation and suckling. Offspring behavior was tested at weaning age or adulthood, and a cross-foster design was employed in a separate cohort to differentiate between effects of prenatal and postnatal maternal B-GOS intake. Lipopolysaccharide was also administered to pups at postnatal day 9 to determine whether maternal B-GOS influences the neurobiological and behavioral effects of a neonatal pro-inflammatory challenge in adulthood. Fecal microbiome composition and metabolites were analyzed to explore potential relationships between the maternal microbiome, the offspring gut microbiome, and the offspring brain and behavior. Maternal B-GOS supplementation increased exploratory behavior and reduced expression of hippocampal glutamate receptor genes in young, weaning-age offspring. In addition, postnatal, but not prenatal, B-GOS supplementation increased fecal butyrate and propionate levels. Finally, in adult offspring, perinatal B-GOS intake increased cortical glutamate receptor subunits in females, increased social preference, and reduced anxiety. We provide novel and comprehensive evidence for the influence of maternal prebiotic intake on offspring behavior, brain gene expression, and gut microbiome composition in mice.

First Authors:
Jenna C Hebert

Correspondence Authors:
Daniel C Anthony,Philip W J Burnet

All Authors:
Jenna C Hebert,Daniel E Radford-Smith,Fay Probert,Nicholas Ilott,Ka Wai Chan,Daniel C Anthony,Philip W J Burnet

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