Abstract & Authors:展开
Metabolic responses to food influence risk of cardiometabolic disease, but large-scale high-resolution studies are lacking. We recruited n = 1,002 twins and unrelated healthy adults in the United Kingdom to the PREDICT 1 study and assessed postprandial metabolic responses in a clinical setting and at home. We observed large inter-individual variability (as measured by the population coefficient of variation (s.d./mean, %)) in postprandial responses of blood triglyceride (103%), glucose (68%) and insulin (59%) following identical meals. Person-specific factors, such as gut microbiome, had a greater influence (7.1% of variance) than did meal macronutrients (3.6%) for postprandial lipemia, but not for postprandial glycemia (6.0% and 15.4%, respectively); genetic variants had a modest impact on predictions (9.5% for glucose, 0.8% for triglyceride, 0.2% for C-peptide). Findings were independently validated in a US cohort (n = 100 people). We developed a machine-learning model that predicted both triglyceride (r = 0.47) and glycemic (r = 0.77) responses to food intake. These findings may be informative for developing personalized diet strategies. The ClinicalTrials.gov registration identifier is NCT03479866.
Sarah E Berry,Ana M Valdes
Ana M Valdes,Tim D Spector
Sarah E Berry,Ana M Valdes,David A Drew,Francesco Asnicar,Mohsen Mazidi,Jonathan Wolf,Joan Capdevila,George Hadjigeorgiou,Richard Davies,Haya Al Khatib,Christopher Bonnett,Sajaysurya Ganesh,Elco Bakker,Deborah Hart,Massimo Mangino,Jordi Merino,Inbar Linenberg,Patrick Wyatt,Jose M Ordovas,Christopher D Gardner,Linda M Delahanty,Andrew T Chan,Nicola Segata,Paul W Franks,Tim D Spector