Nature子刊:调菌群抗肥胖,生命早期是关键
创作:mildbreeze 审核:mildbreeze 08月26日
  • 野化小鼠的肠道菌群,能帮助抵抗成年后长期高脂饮食诱导的肥胖、严重脂肪肝病和代谢综合征;
  • 普通小鼠必须在生命早期(出生后2周内)获得野化菌群,才能拥有这种代谢保护作用,而成年后移植野化菌群或用抗生素扰动野化小鼠的菌群,都不影响其对高脂饮食的应答;
  • 生命早期的肠道菌群能影响宿主的代谢编程,野化菌群主要通过促进分泌代谢激素(如PYY、TSH等)和增强棕色脂肪组织能量消耗,来发挥代谢保护作用。
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mildbreeze
Nature Metabolism近期发表的研究发现,在出生后的生命早期定植源自野外小鼠的肠道菌群,能帮助小鼠抵御成年后的食源性肥胖和代谢疾病。提示对于通过调控菌群来改善代谢健康,生命早期是一个重要的干预窗口期。
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Nature Metabolism [IF:13.511]

Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity

新生儿期暴露于源自野外的微生物组能保护小鼠抵抗食源性肥胖

10.1038/s42255-021-00439-y

08-20, Article

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Obesity and its consequences are among the greatest challenges in healthcare. The gut microbiome is recognized as a key factor in the pathogenesis of obesity. Using a mouse model, we show here that a wild-derived microbiome protects against excessive weight gain, severe fatty liver disease and metabolic syndrome during a 10-week course of high-fat diet. This phenotype is transferable only during the first weeks of life. In adult mice, neither transfer nor severe disturbance of the wild-type microbiome modifies the metabolic response to a high-fat diet. The protective phenotype is associated with increased secretion of metabolic hormones and increased energy expenditure through activation of brown adipose tissue. Thus, we identify a microbiome that protects against weight gain and its negative consequences through metabolic programming in early life. Translation of these results to humans may identify early-life therapeutics that protect against obesity.

First Authors:
Benedikt Hild

Correspondence Authors:
Barbara Rehermann

All Authors:
Benedikt Hild,Matthew S Dreier,Ji Hoon Oh,John A McCulloch,Jonathan H Badger,Juen Guo,Claire E Thefaine,Regina Umarova,Kevin D Hall,Oksana Gavrilova,Stephan P Rosshart,Giorgio Trinchieri,Barbara Rehermann

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Nature Metabolism期刊

A wild approach to obesity prevention

2021-08-20

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