幽门螺杆菌阳性及阴性胃炎患者的胃部菌群差异
创作:海盗船长 审核:szx 2019年04月25日
  • 纳入11名幽门螺杆菌阴性胃炎(HpN)患者,40名幽门螺杆菌阳性胃炎(HpP)患者和24名幽门螺杆菌阴性非胃炎对照;
  • 与HpN或对照组相比,HpP组的胃部菌群丰富度(包括OTU数量、Shannon和Simpson指数)显著降低;
  • HpN组的胃部菌群中厚壁菌门、梭杆菌门、拟杆菌门、放线菌门相对富集;
  • 校正年龄因素后,链球菌和副流感嗜血杆菌丰度与患HpN风险呈正相关,三组中只有HpN组发现密螺旋体;
  • 链球菌、副流感嗜血杆菌和密螺旋体是HpN的潜在致病菌。
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来自《Cancers》上发表的一项最新研究,对比分析了胃癌高发地区中幽门螺杆菌阴性胃炎、幽门螺杆菌阳性胃炎及幽门螺杆菌阴性健康人的胃部菌群差异,发现幽门螺杆菌阳性患者菌群的丰度度显著下降,阴性患者菌群中存在潜在病原菌,该结果对于研究幽门螺杆菌患者的胃部菌群特征、探究潜在致病菌具有参考价值。
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Cancers [IF:6.126]

Gastric Microbiota in Helicobacter pylori-Negative and-Positive Gastritis Among High Incidence of Gastric Cancer Area

胃癌高发地区幽门螺杆菌阳性和阴性胃炎患者中胃部菌群的研究

10.3390/cancers11040504

2019-04-10, Article

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Helicobacter pylori (H. pylori) related chronic gastritis is a well-known major etiological factor for gastric cancer development. However, H. pylori-negative gastritis (HpN) is not well described. We aimed to examine gastric mucosal microbiota in HpN compared to H. pylori-positive gastritis (HpP) and H. pylori-negative non-gastritis group (control). Here, we studied 11 subjects with HpN, 40 with HpP and 24 controls. We performed endoscopy with six gastric biopsies. Comparison groups were defined based on strict histological criteria for the disease and H. pylori diagnosis. We used 16S rRNA gene amplicon sequencing to profile the gastric microbiota according to comparison groups. These results demonstrate that the HpP group had significantly lower bacterial richness by the operational taxonomic unit (OTU) counts, and Shannon and Simpson indices as compared to HpN or controls. The linear discriminant analysis effect size analysis showed the enrichment of Firmicutes, Fusobacteria, Bacteroidetes and Actinobacteria at phylum level in the HpN group. In the age-adjusted multivariate analysis, Streptococcus sp. and Haemophilus parainfluenzae were at a significantly increased risk for HpN (odds ratio 18.9 and 12.3, respectively) based on abundance. Treponema sp. was uniquely found in HpN based on occurrence. In this paper, we conclude that Streptococcus sp., Haemophilus parainfluenzae and Treponema sp. are candidate pathogenic bacterial species for HpN. These results if confirmed may have important clinical implications.

First Authors:
Boldbaatar Gantuya

Correspondence Authors:
Yoshio Yamaoka

All Authors:
Boldbaatar Gantuya,Hashem B El-Serag,Takashi Matsumoto,Nadim J Ajami,Khasag Oyuntsetseg,Dashdorj Azzaya,Tomohisa Uchida,Yoshio Yamaoka

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