江南大学团队:益生菌或可改善功能性便秘
创作:王文东 审核:szx 2020年02月29日
  • 纳入15项符合条件的随机对照试验进行荟萃分析,评估益生菌对功能性便秘的效果;
  • 摄入益生菌使整体肠道通过时间(GTT)显著降低13.75h,显著增加每周的排便频率(0.98次),且摄入多菌种益生菌(至少2种细菌)的效果更显著;
  • 单独摄入乳酸双歧杆菌或长双歧杆菌无上述效果;
  • 含有至少2种细菌的多菌种益生菌(而非单一菌种益生菌)可显著改善粪便硬度并显著减少腹胀;
  • 因报告不充分,导致实施偏倚较高而检出偏倚不明确。
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来自江南大学的翟齐啸团队在Clinical Nutrition上发表的一项荟萃分析,对15项RCT的数据进行总结后发现,补充益生菌可显著降低肠道通过时间,显著增加排便频率,改善粪便硬度,缓解腹胀,且多菌种益生菌的效果更好。
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Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults

益生菌对成人功能性便秘的影响:对RCT的荟萃分析

10.1016/j.clnu.2020.01.005

2020-01-14, Article

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Background & aims: Clinical trials have reported controversial results regarding the effectiveness of probiotics in alleviating functional constipation in adults. We reviewed relevant randomized controlled trials to elucidate the effectiveness of probiotics on constipation symptoms in adults with functional constipation.
Methods: We searched Medline, the Cochrane Library, Web of Science, and Google Scholar for relevant articles published up to April 2019. The primary outcomes of interest were stool frequency, gut transit time (GTT), stool consistency, and bloating. Two authors independently performed the study selection, risk-of-bias assessment, and data extraction. The outcome data were extracted from each included study and synthesized using weighted mean differences (WMDs) or standardized mean differences (SMDs). Pooled data synthesis was performed using a random-effects model.
Results: In total, 2327 relevant studies were identified, 15 of which were found to be eligible randomized controlled trials and were included in the meta-analysis. Pooling of the extracted data demonstrated that probiotic consumption significantly reduced the whole GTT by 13.75 h [95% confidence interval (CI): −21.93 to −5.56 h] and increased the stool frequency by 0.98 (95% CI: 0.36 to 1.60) bowel movements per week. This increase was significant with the consumption of multispecies probiotics [at least two bacteria; WMD: 1.22 (95% CI: 0.50 to 1.94) bowel movements per week] but not with the consumption of Bifidobacterium lactis [WMD: 1.34 (95% CI: −0.27 to 2.94) bowel movements per week] or B. longum [WMD: −0.02 (95% CI: −0.56 to 0.53) bowel movements per week] alone. Multispecies probiotics (WMD: 1.37; 95% CI: 0.72 to 2.01), but not single-species probiotics (WMD: 1.18; 95% CI: −0.59 to 2.96), improved stool consistency (WMD: 1.30; 95% CI: 0.22 to 2.38). Similarly, multispecies probiotics (at least two bacteria; WMD: −0.49; 95% CI: −0.85 to −0.13), but not single-species probiotics (WMD: −0.24; 95% CI: −0.55 to 0.07), significantly decreased bloating. Performance bias were high, whereas detection bias was unclear because of inadequate reporting.
Conclusion: Consumption of probiotics, in particular, multispecies probiotics, may substantially reduce the GTT, increase the stool frequency, and improve the stool consistency. Thus, probiotics can be regarded as safe and natural agents for alleviation of functional constipation in adults.

First Authors:
Chengcheng Zhang

Correspondence Authors:
Qixiao Zhai,Wei Chen

All Authors:
Chengcheng Zhang,Jinchi Jiang,Fengwei Tian,Jianxin Zhao,Hao Zhang,Qixiao Zhai,Wei Chen

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