任文凯团队:详解肠道真菌群与健康和疾病(综述)
创作:大月半 审核:mildbreeze 05月01日
  • 肠道真菌的研究方法以培养和测序为主;
  • 对肠道真菌群的定殖和组成特征的研究仍处于起步阶段,分娩方式、膳食营养、环境和季节等因素可影响肠道真菌的组成;
  • 肠道真菌群通过自身组分、直接代谢产物、提取物及次生代谢物与宿主免疫互作,可能对IBD、乳糜泻、肠癌和IBS等肠道疾病造成影响;
  • 肠道真菌群还可通过肠肺轴、肠脑轴和肠肝轴,甚至肠肾轴和肠胰腺轴,影响远端组织疾病和生理功能;
  • 肠道真菌可为各种疾病的诊断和治疗提供新机遇。
主编推荐语
mildbreeze
真菌在肠道微生物中的占比较小,但与其它肠道微生物一样,肠道真菌对肠道和肠外远端器官的生理功能都有重要的调控作用。华南农业大学任文凯团队与合作者近期在Microbiome发表重要综述,对肠道真菌群在健康与疾病中的作用进行了深入探讨,推荐专业人士学习和参考。
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Microbiome [IF:11.607]

Intestinal mycobiota in health and diseases: from a disrupted equilibrium to clinical opportunities

疾病和健康中的肠道真菌群:从平稳破坏到临床机遇

10.1186/s40168-021-01024-x

03-14, Review

Abstract & Authors:展开

Abstract:收起
Bacteria, viruses, protozoa, and fungi establish a complex ecosystem in the gut. Like other microbiota, gut mycobiota plays an indispensable role in modulating intestinal physiology. Notably, the most striking characteristics of intestinal fungi are their extraintestinal functions. Here, we provide a comprehensive review of the importance of gut fungi in the regulation of intestinal, pulmonary, hepatic, renal, pancreatic, and brain functions, and we present possible opportunities for the application of gut mycobiota to alleviate/treat human diseases.

First Authors:
Xiaoyan Wu,Yaoyao Xia

Correspondence Authors:
Congrui Zhu,Wenkai Ren

All Authors:
Xiaoyan Wu,Yaoyao Xia,Fang He,Congrui Zhu,Wenkai Ren

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