Abstract & Authors:展开
The intestinal microbiota shape the host immune system and influence the outcomes of various neurological disorders. Arteriosclerotic cerebral small vessel disease (aCSVD) is highly prevalent among the elderly with its pathological mechanisms yet is incompletely understood. The current study investigated the ecology of gut microbiota in patients with aCSVD, particularly its impact on the host immune system. We reported that the altered composition of gut microbiota was associated with undesirable disease outcomes and exacerbated inflammaging status. When exposed to the fecal bacterial extracts from a patient with aCSVD, human and mouse neutrophils were activated, and capacity of interleukin-17A (IL-17A) production was increased. Mechanistically, RORγt signaling in neutrophils was activated by aCSVD-associated gut bacterial extracts to up-regulate IL-17A production. Our findings revealed a previously unrecognized implication of the gut-immune-brain axis in aCSVD pathophysiology, with therapeutic implications.
Wei Cai,Xiaodong Chen
Andy Peng Xiang,Zhengqi Lu
Wei Cai,Xiaodong Chen,Xuejiao Men,Hengfang Ruan,Mengyan Hu,Sanxin Liu,Tingting Lu,Jinchi Liao,Bingjun Zhang,Danli Lu,Yinong Huang,Ping Fan,Junping Rao,Chunyan Lei,Jihui Wang,Xiaomeng Ma,Qiang Zhu,Lili Li,Xiuyun Zhu,Yujiao Hou,Shu Li,Qing Dong,Qing Tian,Lulu Ai,Wenjing Luo,Mengyun Zuo,Liping Shen,Congyan Xie,Hongzhong Song,Ganlin Xu,Kangdi Zheng,Zhao Zhang,Yongjun Lu,Wei Qiu,Tao Chen,Andy Peng Xiang,Zhengqi Lu