中山三院:肠道菌群可参与动脉硬化性脑小血管病的发病
创作:szx 审核:szx 01月26日
  • aCSVD患者的肠道菌群多样性增加,菌群组成显著不同于健康对照;
  • aCSVD患者的肠道菌群变化与神经影像学标志物及MoCA评分(用于评估认知功能)相关,并与炎症相关慢性衰老的速率增加相关;
  • 在体外共培养中,aCSVD患者的肠道菌群可增加人及小鼠的原代中性粒细胞产生的IL-17A;
  • aCSVD患者的粪便细菌提取物可通过激活RORγt信号,增加中性粒细胞的IL-17A表达。
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szx
动脉硬化性脑小血管病(aCSVD)是老年人中的高发疾病,发病机制尚未完全明确。中山大学附属第三医院的陆正齐团队与项鹏团队在Science Advances上发表的一项最新研究,发现aCSVD患者的肠道菌群多样性及组成均发生显著变化,且菌群变化与神经影像学及认知功能量表评分相关。在体外,aCSVD患者的菌群或细菌提取物可通过激活RORγt信号,增加中性粒细胞的IL-17A表达。该研究结果提示,菌群-肠-脑-免疫轴在aCSVD的发病机制中起到重要作用。
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Science Advances [IF:13.116]

Gut microbiota from patients with arteriosclerotic CSVD induces higher IL-17A production in neutrophils via activating RORγt

动脉硬化性脑小血管病患者的肠道菌群通过激活RORγt诱导中性粒细胞产生更多的IL-17A

10.1126/sciadv.abe4827

01-22, Article

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The intestinal microbiota shape the host immune system and influence the outcomes of various neurological disorders. Arteriosclerotic cerebral small vessel disease (aCSVD) is highly prevalent among the elderly with its pathological mechanisms yet is incompletely understood. The current study investigated the ecology of gut microbiota in patients with aCSVD, particularly its impact on the host immune system. We reported that the altered composition of gut microbiota was associated with undesirable disease outcomes and exacerbated inflammaging status. When exposed to the fecal bacterial extracts from a patient with aCSVD, human and mouse neutrophils were activated, and capacity of interleukin-17A (IL-17A) production was increased. Mechanistically, RORγt signaling in neutrophils was activated by aCSVD-associated gut bacterial extracts to up-regulate IL-17A production. Our findings revealed a previously unrecognized implication of the gut-immune-brain axis in aCSVD pathophysiology, with therapeutic implications.

First Authors:
Wei Cai,Xiaodong Chen

Correspondence Authors:
Andy Peng Xiang,Zhengqi Lu

All Authors:
Wei Cai,Xiaodong Chen,Xuejiao Men,Hengfang Ruan,Mengyan Hu,Sanxin Liu,Tingting Lu,Jinchi Liao,Bingjun Zhang,Danli Lu,Yinong Huang,Ping Fan,Junping Rao,Chunyan Lei,Jihui Wang,Xiaomeng Ma,Qiang Zhu,Lili Li,Xiuyun Zhu,Yujiao Hou,Shu Li,Qing Dong,Qing Tian,Lulu Ai,Wenjing Luo,Mengyun Zuo,Liping Shen,Congyan Xie,Hongzhong Song,Ganlin Xu,Kangdi Zheng,Zhao Zhang,Yongjun Lu,Wei Qiu,Tao Chen,Andy Peng Xiang,Zhengqi Lu

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