FMT重建肠道内的IgA-菌群互作
  • 评估48例复发性艰难梭菌感染患者在粪菌移植(FMT)治疗前后的粪便IgA-细菌互作;
  • FMT前,患者肠道菌群的失调特征以IgA结合的大肠杆菌为主;
  • FMT后,患者的IgA结合菌群增加,包括多个厚壁菌门物种;
  • FMT后的IgA-细菌互作不受给药途径(结肠镜或口服粪菌胶囊)的影响,两种方式都能在受体肠道中建立健康的免疫-细菌相互作用;
  • FMT受体的菌群的IgA靶向模式与供体相似,提示细菌的内在特性驱动了人肠道中的IgA-菌群互作。
主编推荐语
mildbreeze
分泌型免疫球蛋白A(IgA)与肠道菌群相互作用,促进黏膜稳态。IgA与细菌的互作在炎症性疾病中发生改变,细菌、宿主和环境因素怎样影响IgA-菌群互作尚不清楚。Gut Microbes发表的一项研究表明,粪菌移植(FMT)能在很大程度上重塑复发性艰难梭菌感染(rCDI)患者肠道中的IgA-菌群互作模式,使之趋向于健康粪便供体。相关发现有助于理解FMT治疗rCDI等疾病的机制,以及IgA-菌群相互作用的生物学规律。
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Gut Microbes [IF:7.74]

Changes in IgA-targeted microbiota following fecal transplantation for recurrent Clostridioides difficile infection

粪菌移植治疗复发性艰难梭菌感染后的IgA靶向菌群的变化

10.1080/19490976.2020.1862027

2020-12-31, Article

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Secretory immunoglobulin A (IgA) interacts with intestinal microbiota and promotes mucosal homeostasis. IgA-bacteria interactions are altered during inflammatory diseases, but how these interactions are shaped by bacterial, host, and environmental factors remains unclear. In this study, we utilized IgA-SEQ to profile IgA-bound fecal bacteria in 48 recurrent Clostridioides difficile patients before and after successful fecal microbiota transplantation (FMT) to gain further insight. Prior to FMT, Escherichia coli was the most highly IgA-targeted taxon; following restoration of the microbiota by FMT, highly IgA-targeted taxa included multiple Firmicutes species. Post-FMT IgA-targeting was unaffected by the route of FMT delivery (colonoscopy versus capsule), suggesting that both methods lead to the establishment of healthy immune–bacterial interactions in the gut. Interestingly, IgA-targeting in FMT recipients closely resembled the IgA-targeting patterns of the donors, and fecal donor identity was significantly associated with IgA-targeting of the recipient microbiota. These data support the concept that intrinsic bacterial properties drive IgA recognition across genetically distinct human hosts. Together, this study suggests that IgA-bacterial interactions are reestablished in human FMT recipients to resemble that of the healthy fecal donor.

First Authors:
Kelsey E Huus

Correspondence Authors:
Tanya M Monaghan

All Authors:
Kelsey E Huus,Marcin Frankowski,Maja Pučić-Baković,Frano Vučković,Gordan Lauc,Benjamin H Mullish,Julian Marchesi,Tanya M Monaghan,Dina Kao,B Brett Finlay

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