杨鹏辉&王军团队:新冠肺炎患者的特征肠道病毒和细菌组
创作:Johnson 审核:周旸 03月31日
  • 13例新冠肺炎患者的肠道细菌组多样性低于健康人群,不同患者中肠道病毒组的丰度变化趋势不同;
  • 病毒组与细菌组存在强相关性,肠道中新冠病毒的相对丰度非常低;
  • 抗生素治疗对细菌组的影响大于病毒组,各有不同的细菌、病毒群落差异分布于症状严重程度不同的患者体内;
  • 重症患者肠道中条件致病细菌较多,产丁酸细菌较低;
  • 未接种疫苗的小鼠感染新冠病毒后,肠道内发生病毒组变化和细菌组紊乱,肠上皮中免疫/感染相关基因表达发生变化。
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周旸
肠道是新冠病毒感染的器官之一,研究肠道微生态在新冠肺炎发生发展中的作用或有助于新冠肺炎的诊疗。中国解放军总医院杨鹏辉团队和中科院王军团队近期在Gut Microbes发表研究,对比了13名新冠肺炎患者与5名健康人的肠道细菌组与病毒组变化规律,发现两者的组成和变化在新冠患者中具有特殊性,受药物的影响也各有不同,而且在不同疾病严重程度的患者中具有差异。上述结果在小鼠实验中得到证实。本研究的成果,对于研究新冠肺炎的病程特征、感染过程中共生微生态-宿主互作都具有参考价值。
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Gut Microbes [IF:7.74]

Integrated gut virome and bacteriome dynamics in COVID-19 patients

COVID-19患者的肠道病毒组和细菌组整体动力学

10.1080/19490976.2021.1887722

03-08, Article

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SARS-CoV-2 is the cause of the current global pandemic of COVID-19; this virus infects multiple organs, such as the lungs and gastrointestinal tract. The microbiome in these organs, including the bacteriome and virome, responds to infection and might also influence disease progression and treatment outcome. In a cohort of 13 COVID-19 patients in Beijing, China, we observed that the gut virome and bacteriome in the COVID-19 patients were notably different from those of five healthy controls. We identified a bacterial dysbiosis signature by observing reduced diversity and viral shifts in patients, and among the patients, the bacterial/viral compositions were different between patients of different severities, although these differences are not entirely distinguishable from the effect of antibiotics. Severe cases of COVID-19 exhibited a greater abundance of opportunistic pathogens but were depleted for butyrate-producing groups of bacteria compared with mild to moderate cases. We replicated our findings in a mouse COVID-19 model, confirmed virome differences and bacteriome dysbiosis due to SARS-CoV-2 infection, and observed that immune/infection-related genes were differentially expressed in gut epithelial cells during infection, possibly explaining the virome and bacteriome dynamics. Our results suggest that the components of the microbiome, including the bacteriome and virome, are affected by SARS-CoV-2 infections, while their compositional signatures could reflect or even contribute to disease severity and recovery processes.

First Authors:
Jiabao Cao,Cheng Wang,Yuqing Zhang,Guanglin Lei

Correspondence Authors:
Jun Wang,Penghui Yang

All Authors:
Jiabao Cao,Cheng Wang,Yuqing Zhang,Guanglin Lei,Kun Xu,Na Zhao,Jingjing Lu,Fanping Meng,Linxiang Yu,Jin Yan,Changqing Bai,Shaogeng Zhang,Ning Zhang,Yuhuan Gong,Yuhai Bi,Yi Shi,Zhu Chen,Lianpan Dai,Jun Wang,Penghui Yang

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