一文读懂生物钟、进食时间、菌群和免疫的亲密关系(综述)
创作:mildbreeze 审核:mildbreeze 05月01日
  • 生物钟、进食节律、肠道菌群和免疫系统之间存在密切互作;
  • 宿主生物钟和饮食可影响进食节律,驱动肠道菌群组成和功能的每日节律性变化;
  • 肠道菌群整合营养、激素和先天免疫感应的信号,通过影响表观遗传和基因表达等机制,协调宿主的肠道和远端组织(如肝脏)的节律性;
  • 禁食/进食循环模式对先天和适应性免疫都有巨大影响(如免疫细胞振荡和运输);
  • 饮食-生物钟互作参与多种免疫相关疾病,时间营养学是潜在的疾病管理手段。
主编推荐语
mildbreeze
生物体的昼夜节律和进食时间存在相互调控和协调,对免疫和代谢健康等生理功能有重要影响。近期研究表明,饮食节律与免疫的相互作用,可能受肠道菌群的调节。《Trends in Immunology》最新发表了来自Eran Elinav团队的重要综述,介绍了进食时间、昼夜节律、肠道菌群与免疫系统之间的相互作用,及其对免疫相关疾病的影响,并探讨了调节进食时间以协调身体节律的时间营养学方法在相关疾病干预中的应用前景。
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Circadian Influences of Diet on the Microbiome and Immunity

饮食对微生物组和免疫的节律性影响

10.1016/j.it.2020.04.005

04-28, Review

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Host circadian rhythmicity and the timing of feeding are increasingly recognized to cross-regulate and entrain each other, and may play crucial roles in regulating multiple physiological functions including host immunity and metabolic health. Of relevance, these circadian diet–immune interactions may be modulated by the gut microbiota. We review current knowledge linking the circadian clock and dietary timing to host immune–microbiota interactions, exemplifying how this axis may impact on host immunity in health and in a variety of immune-mediated diseases. We also discuss current challenges in reaching mechanistic insights regarding the functions of the diurnally shifting diet–microbiome–host immune axis. We highlight the possible implications of circadian reprogramming by dietary timing patterns as a future intervention to modulate a variety of immune-related diseases.

First Authors:
Danping Zheng,Karina Ratiner

Correspondence Authors:
Eran Elinav

All Authors:
Danping Zheng,Karina Ratiner,Eran Elinav

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