Abstract & Authors:展开
Host circadian rhythmicity and the timing of feeding are increasingly recognized to cross-regulate and entrain each other, and may play crucial roles in regulating multiple physiological functions including host immunity and metabolic health. Of relevance, these circadian diet–immune interactions may be modulated by the gut microbiota. We review current knowledge linking the circadian clock and dietary timing to host immune–microbiota interactions, exemplifying how this axis may impact on host immunity in health and in a variety of immune-mediated diseases. We also discuss current challenges in reaching mechanistic insights regarding the functions of the diurnally shifting diet–microbiome–host immune axis. We highlight the possible implications of circadian reprogramming by dietary timing patterns as a future intervention to modulate a variety of immune-related diseases.
Danping Zheng,Karina Ratiner
Danping Zheng,Karina Ratiner,Eran Elinav