创作:szx 审核:szx 2020年12月06日
  • 纳入12名健康成年人,随机先后进行正常时间进食或延迟进食,每种饮食干预的能量摄入及宏量营养素含量相当,各持续8周,中间2周清洗期;
  • 正常时间进食为每日8点-19点进食,延迟进食为每日12点-23点进食,干预期间保持睡眠周期及锻炼水平一致;
  • 相比于延迟进食,正常时间进食可显著降低受试者的体重、胰岛素抵抗、躯干/腿部脂肪比、静息时能量消耗、呼吸熵;
  • 并降低空腹血糖、胰岛素、总胆固醇、HDL胆固醇、脂联素及甘油三酯的水平。
延迟进食与肥胖及代谢失调风险的增加相关。Current Biology上发表的一项随机交叉对照试验,对比了正常时间进食与延迟进食对健康成年人的体重及各项重要代谢指标的影响,发现相比于延迟进食,正常时间进食的饮食模式可显著降低体重,并改善胰岛素抵抗、空腹血糖、总胆固醇、能量消耗等大多数代谢指标。
Current Biology [IF:9.601]

Prolonged, Controlled Daytime versus Delayed Eating Impacts Weight and Metabolism



2020-11-30, Article

Abstract & Authors:展开

A delayed eating schedule is associated with increased risk of obesity and metabolic dysfunction in humans.1, 2, 3, 4, 5, 6, 7, 8, 9 However, there are no prolonged, highly controlled experimental studies testing the effects of meal timing on weight and metabolism in adults with a body mass index (BMI) of 19–27 kg/m2.10, 11, 12, 13, 14, 15, 16, 17, 18 Twelve healthy adults (age: 26.3 ± 3.4 years; BMI: 21.9 ± 1.7 kg/m2; 5 females) participated in a randomized crossover study in free-living conditions. Three meals and two snacks with comparable energy and macronutrient contents were provided during two, 8-week, counterbalanced conditions separated by a 2-week washout period: (1) daytime (intake limited to 0800 h–1900 h) and (2) delayed (intake limited to 1200 h–2300 h). Sleep-wake cycles and exercise levels were held constant. Weight, adiposity, energy expenditure, and circadian profiles of hormones and metabolites were assessed during four inpatient visits occurring before and after each condition. Body weight, insulin resistance (homeostatic model assessment of insulin resistance [HOMA-IR]), trunk-to-leg fat ratio, resting energy expenditure, respiratory quotient, and fasting glucose, insulin, total and high-density lipoprotein (dHDL) cholesterol, and adiponectin decreased on the daytime compared to the delayed schedule. These measures, as well as triglycerides, increased on the delayed compared to the daytime schedule (effect size range: d = 0.397–1.019). Circadian phase and amplitude of melatonin, cortisol, ghrelin, leptin, and glucose were not differentially altered by the eating schedules. Overall, an 8-week daytime eating schedule, compared to a delayed eating schedule, promotes weight loss and improvements in energy metabolism and insulin in adults with BMI 19–27 kg/m2, underscoring the efficacy and feasibility of daytime eating as a behavioral modification for real-world conditions.

First Authors:
Kelly C Allison

Correspondence Authors:
Kelly C Allison

All Authors:
Kelly C Allison,Christina M Hopkins,Madelyn Ruggieri,Andrea M Spaeth,Rexford S Ahima,Zhe Zhang,Deanne M Taylor,Namni Goel