Abstract & Authors:展开
The physical appearance of tongue coatings is vital for traditional Chinese medicine (TCM) to diagnose health and disease status. The microbiota of different tongue coatings could also influence coating formation and be further associated with specific diseases. Previous studies have focused on bacteria from different tongue coatings in the context of specific diseases, but the normal variations in healthy individuals remain unknown. We examined the tongue microbiota by metagenomics in 94 healthy individuals classified into eight different tongue types. The overall composition of the tongue coating microbiome is not drastically different among different coating types, similar to the findings of previous studies in healthy populations. Further analysis revealed microbiota characteristics of each coating type, and many of the key bacteria are reported to be implicated in diseases. Moreover, further inclusion of diabetic patients revealed disease-specific enrichment of , even though the same tongue coatings were studied. This work revealed the characteristic compositions of distinctive tongue coatings in a healthy population, which serves as a basis for understanding the tongue coating formation mechanism and provides a valuable reference to further investigate disease-specific tongue coating bacterial markers.
Hairong Chen,Qingwei Li
Jun Wang,Yixin Zeng,Xiaolin Tong
Hairong Chen,Qingwei Li,Min Li,Sheng Liu,Chensi Yao,Zixiong Wang,Zhuoya Zhao,Ping Liu,Fan Yang,Xinjian Li,Jun Wang,Yixin Zeng,Xiaolin Tong