仝小林+曾益新+王军:菌群分析背书中医望舌诊断?
创作:Johnson 审核:solo 2021年08月25日
  • 纳入94名志愿者收录8种舌苔类型,并采用宏基因组分析舌苔微生物群落;
  • 发现舌苔类型在健康人群中分布不均,但相应舌苔微生物组及其β多样性无显著差异;
  • 不同舌苔类型中疾病相关特征菌丰度不同,白色宽厚油腻舌苔类型中胃炎、癌前胃炎相关致病菌富集;
  • 黄色窄薄舌苔类型中机会致病菌富集,而黄色宽厚油腻舌苔鳞状细胞癌相关致病菌富集;
  • 相同的舌苔类型中,糖尿病患者菌群有别于常人,二氧化碳嗜纤维菌属富集。
主编推荐语
solo
望舌是通过察看舌质和舌苔的形态、色泽、润燥等方面的变化测知病情变化的一种独具特色的诊法,在中医诊断中占有重要地位。近日中国中医科学院广安门医院仝小林院士、中科院生物物理所曾益新、中科院微生物所王军及团队在Journal of Oral Microbiology发表文章,阐述健康人群中不同舌苔类型的微生物特征及其与疾病的潜在关联。
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Microbial characteristics across different tongue coating types in a healthy population

健康人群中不同舌苔类型的微生物特征

10.1080/20002297.2021.1946316

2021-07-26, Article

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The physical appearance of tongue coatings is vital for traditional Chinese medicine (TCM) to diagnose health and disease status. The microbiota of different tongue coatings could also influence coating formation and be further associated with specific diseases. Previous studies have focused on bacteria from different tongue coatings in the context of specific diseases, but the normal variations in healthy individuals remain unknown. We examined the tongue microbiota by metagenomics in 94 healthy individuals classified into eight different tongue types. The overall composition of the tongue coating microbiome is not drastically different among different coating types, similar to the findings of previous studies in healthy populations. Further analysis revealed microbiota characteristics of each coating type, and many of the key bacteria are reported to be implicated in diseases. Moreover, further inclusion of diabetic patients revealed disease-specific enrichment of , even though the same tongue coatings were studied. This work revealed the characteristic compositions of distinctive tongue coatings in a healthy population, which serves as a basis for understanding the tongue coating formation mechanism and provides a valuable reference to further investigate disease-specific tongue coating bacterial markers.

First Authors:
Hairong Chen,Qingwei Li

Correspondence Authors:
Jun Wang,Yixin Zeng,Xiaolin Tong

All Authors:
Hairong Chen,Qingwei Li,Min Li,Sheng Liu,Chensi Yao,Zixiong Wang,Zhuoya Zhao,Ping Liu,Fan Yang,Xinjian Li,Jun Wang,Yixin Zeng,Xiaolin Tong

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