Nature子刊:纯母乳喂养怎样影响婴儿的肠道菌群?
  • 纳入7项不同人群研究(近700名婴儿),对纯母乳喂养(EBF)和非EBF的婴儿肠道菌群数据进行荟萃分析;
  • 出生后6个月内,肠道细菌多样性、菌群年龄、拟杆菌门和厚壁菌门相对丰度、碳水化合物代谢相关菌群通路,在非EBF婴儿中较高;
  • 而脂代谢、维生素代谢、解毒相关通路的相对丰度在EBF婴儿中较高;
  • 非EBF婴儿中,菌群通路的差异性在剖腹产婴儿中较大;
  • 延长EBF与腹泻相关肠道菌群失调的减少相关,EBF对菌群的影响可持续至6月龄后。
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mildbreeze
纯母乳喂养(EBF)被认为对婴儿发育和肠道菌群有益,但具体有何影响仍不明确。Nature Communications近期发表一项荟萃分析,纳入不同国家近700名婴儿的肠道菌群数据,分析了EBF和非EBF对婴儿肠道菌群组成和功能的不同影响,为阐释EBF的某些短期和长期健康益处提供了一些可能的机制。
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Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations

不同人群中纯母乳喂养对婴儿肠道菌群的影响的荟萃分析

10.1038/s41467-018-06473-x

2018-10-09, Article

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Previous studies on the differences in gut microbiota between exclusively breastfed (EBF) and non-EBF infants have provided highly variable results. Here we perform a meta-analysis of seven microbiome studies (1825 stool samples from 684 infants) to compare the gut microbiota of non-EBF and EBF infants across populations. In the first 6 months of life, gut bacterial diversity, microbiota age, relative abundances of Bacteroidetes and Firmicutes, and predicted microbial pathways related to carbohydrate metabolism are consistently higher in non-EBF than in EBF infants, whereas relative abundances of pathways related to lipid metabolism, vitamin metabolism, and detoxification are lower. Variation in predicted microbial pathways associated with non-EBF infants is larger among infants born by Caesarian section than among those vaginally delivered. Longer duration of exclusive breastfeeding is associated with reduced diarrhea-related gut microbiota dysbiosis. Furthermore, differences in gut microbiota between EBF and non-EBF infants persist after 6 months of age. Our findings elucidate some mechanisms of short and long-term benefits of exclusive breastfeeding across different populations.

First Authors:
Nhan T. Ho

Correspondence Authors:
Louise Kuhn

All Authors:
Nhan T Ho,Fan Li,Kathleen A Lee-Sarwar,Hein M Tun,Bryan P Brown,Pia S Pannaraj,Jeffrey M Bender,Meghan B Azad,Amanda L Thompson,Scott T Weiss,M Andrea Azcarate-Peril,Augusto A Litonjua,Anita L Kozyrskyj,Heather B Jaspan,Grace M Aldrovandi,Louise Kuhn

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