共生菌在蜜蜂免疫系统中的重要作用(综述)
  • 蜜蜂具有独特的核心微生物群,对宿主的抗逆性和抗病性有重要的作用;
  • 杀虫剂、抗生素、寄生虫、营养缺乏或过剩都会损害蜜蜂关键共生菌,降低其免疫力和营养状况并加剧农药毒性;
  • 亚致死剂量的农药暴露较难检测,但可能会不可逆转地损害蜜蜂的微生物群并影响其健康;
  • 使用基因工程共生菌以及具免疫调节作用的益生菌有望通过调节宿主防御系统来“重置”失调的微生物菌群;
  • 应将昆虫微生物群纳入农业化学品风险评估的标准方法。
主编推荐语
EADGBE
农药暴露、感染性疾病和营养威胁导致较高的蜜蜂死亡率和蜂群损失率。尽管对影响昆虫生理的应激因素的单一及综合效应的研究已有数十年之久,但缺少对蜜蜂共生微生物群落在抵抗环境应激方面的作用的研究。在人类中,抗生素的多代连续使用与许多当代疾病有关。近期发表于Trends in Microbiology的一篇综述,作者们对蜜蜂的情况得出了类似的结论,认为长期暴露于外源性抗菌物质会系统性地损伤蜜蜂体内的微生物群,并妨碍对健康至关重要的且适应宿主的共生菌的跨代转移。作者建议,应将对昆虫共生微生物群的影响纳入农业化学品风险评估的考量中。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!

Missing Microbes in Bees: How Systematic Depletion of Key Symbionts Erodes Immunity

蜜蜂缺失的微生物:关键共生菌的系统性缺失如何损坏免疫(综述)

10.1016/j.tim.2020.06.006

2020-07-14, Review

Abstract & Authors:展开

Abstract:收起
Pesticide exposure, infectious disease, and nutritional stress contribute to honey bee mortality and a high rate of colony loss. This realization has fueled a decades-long investigation into the single and combined effects of each stressor and their overall bearing on insect physiology. However, one element largely missing from this research effort has been the evaluation of underlying microbial communities in resisting environmental stressors and their influence on host immunity and disease tolerance. In humans, multigenerational bombardment by antibiotics is linked with many contemporary diseases. Here, we draw a parallel conclusion for the case in honey bees and suggest that chronic exposure to antimicrobial xenobiotics can systematically deplete honey bees of their microbes and hamper cross-generational preservation of host-adapted symbionts that are crucial to health.

First Authors:
Brendan A Daisley

Correspondence Authors:
Gregor Reid

All Authors:
Brendan A Daisley,John A Chmiel,Andrew P Pitek,Graham J Thompson,Gregor Reid

评论