肠道菌群是否与癌症幸存者的复发恐惧存在关联?
创作:吴芹 审核:mildbreeze 2019年03月05日
  • 纳入126名浸润性乳腺癌的妇女,其中57名患者有化疗史,分析粪便菌群与癌症复发恐惧(FCR)的关联;
  • 整体上,拟杆菌属的相对丰度与FCR显著相关;
  • 有化疗史的患者中,与较高的FCR相关的菌群因素包括:较低的菌群多样性、较低的厚壁菌门丰度、较高的拟杆菌门丰度、较高的拟杆菌属丰度、较低的Lachnospiraceae.g和瘤胃球菌属丰度;
  • 无化疗史的患者中,FCR与细菌组成无相关性;
  • 化疗史可能影响肠道菌群与FCR的关联。
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mildbreeze
对癌症复发的恐惧心理,在癌症幸存者中很常见,菌群-肠-脑轴是否参与其中尚不清楚。《Brain Behavior and Immunity》发表的一项最新研究,首次分析了乳腺癌幸存者的肠道菌群与癌症复发恐惧(FCR)间的关联,发现有化疗史的患者中,有些菌群因素与FCR显著相关,这些发现或为改善特定癌症幸存者群体的精神健康提供了新视角。
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Impact of chemotherapy on the association between fear of cancer recurrence and the gut microbiota in breast cancer survivors

化疗对乳腺癌幸存者的癌症复发恐惧和肠道菌群之间关系的影响

10.1016/j.bbi.2019.02.025

2019-02-25, Article

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BACKGROUND: Dysfunctional processing of fear memory may be involved in the pathophysiology of fear of cancer recurrence (FCR), which is cited as the major unmet psychological need of cancer survivors. Emerging evidence has shown that the microbiota-gut-brain (MGB) axis affects depressive and anxiety disorders, and chemotherapy-associated psychological distress. We therefore hypothesized that the gut microbiota is associated with FCR in cancer survivors.
METHODS: This cross-sectional study enrolled women diagnosed with invasive breast cancer who were not currently undergoing chemotherapy. Fecal samples were obtained to assess the gut microbiota. FCR grade was assessed using the Concerns About Recurrence Scale (CARS).
RESULTS: Mean age of the participants (n = 126) was 58 years; 47% had stage I disease. Multiple regression analysis with adjustment for possible confounders showed that the relative abundance of the Bacteroides genus (beta = 0.180, p = 0.03) was significantly and directly associated with FCR. In the 57 participants with a history of chemotherapy, higher FCR was associated with lower microbial diversity (p = 0.04), lower relative abundance of Firmicutes (p = 0.03) and higher relative abundance of Bacteroidetes (p = 0.04) at the phylum level, and higher relative abundance of Bacteroides (p < 0.01) and lower relative abundance of Lachnospiraceae.g (p = 0.03) and Ruminococcus (p = 0.02) at the genus level.
CONCLUSION: Our findings provide the first evidence of an association between the gut microbiota and FCR and suggest that chemotherapy-induced changes in gut microbiota can influence FCR. Further studies should examine the effects of the gut microbiota on FCR using a prospective design.

First Authors:
Ryo Okubo

Correspondence Authors:
Yutaka J Matsuoka

All Authors:
Ryo Okubo,Takayuki Kinoshita,Noriko Katsumata,Yasuhito Uezono,Jinzhong Xiao,Yutaka J Matsuoka

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