Lancet子刊:儿童胃肠疾病的预防性益生菌循证(综述)
创作:大力 审核:mildbreeze 2019年11月02日
  • 特定益生菌菌株可能预防急性肠胃炎、抗生素腹泻、婴儿肠绞痛和坏死性小肠结肠炎;
  • 然而由于研究设计差异,对特定菌株、剂量和适应症的证据有限,目前没有足够的证据支持日常用益生菌预防婴儿和儿童胃肠疾病;
  • 目前证据最强的预防性益生菌:乳双歧杆菌用于急性肠胃炎、布拉酵母菌和鼠李糖乳杆菌GG用于抗生素腹泻、罗伊氏乳杆菌DSM17938用于婴儿肠绞痛、反酸和便秘;
  • 预防性使用益生菌不太可能引起危害,仍需进行更多高质量研究。
主编推荐语
mildbreeze
益生菌预防和治疗胃肠疾病是研究和转化应用的热点领域,The Lancet Child & Adolescent Health发表的一篇重要综述,对相关临床证据进行汇总,值得专业人士关注。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!

Prophylactic use of probiotics for gastrointestinal disorders in children

使用益生菌预防儿童胃肠疾病

10.1016/S2352-4642(19)30182-8

2019-07-03, Review

Abstract & Authors:展开

Abstract:收起
The gastrointestinal microbiome is a hot topic in clinical research. Beneficial effects of selected probiotics in the prevention of gastrointestinal disorders are mainly restricted to acute gastroenteritis, antibiotic-associated diarrhoea, infantile colic, and necrotising enterocolitis. However, no broad consensus exists to recommend the use of probiotics in the prevention of these conditions, mainly because of the different design of the studies done so far, resulting in little evidence for specific strains, dosages, and indications. More well designed studies are needed before recommendations can be proposed. At this stage, the evidence is insufficient to recommend the routine use of probiotics in infants and children for the prevention of gastrointestinal disorders.

First Authors:
Celine Perceval

Correspondence Authors:
Yvan Vandenplas

All Authors:
Celine Perceval,Hania Szajewska,Flavia Indrio,Zvi Weizman,Yvan Vandenplas

评论