合生制剂或能预防轮状病毒感染
创作:szx 审核:szx 2018年06月20日
  • 在大鼠双重轮状病毒感染模型中,分析益生元(低聚半乳糖+低聚果糖)、益生菌(短双歧杆菌M-16V)、合生制剂的作用;
  • 大鼠分别感染SA11及EDIM轮状病毒,饮食干预缓解了首次感染后的腹泻等临床症状;
  • 在第一次感染后,益生元及合生制剂显著降低了病毒播散;
  • 在体外,所有干预均可调节轮状病毒感染后的抗体及细胞因子产生,在体内,可调节肠道中细胞因子的水平及小肠中的基因表达。
主编推荐语
szx
来自Frontiers in Immunology的最新研究,利用含有低聚半乳糖+低聚果糖+短双歧杆菌M-16V的合生制剂,可在大鼠轮状病毒感染中起到保护作用。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!

Preventive effect of a synbiotic combination of galacto-and fructo-oligosaccharides mixture with Bifidobacterium breve M-16V in a model of multiple rotavirus infections

低聚半乳糖+低聚果糖+短双岐杆菌M-16V的合生制剂对多重轮状病毒感染的预防作用

10.3389/fimmu.2018.01318

2018-06-11, Article

Abstract & Authors:展开

Abstract:收起
Rotavirus (RV) causes morbidity and mortality among infants worldwide, and there is evidence that probiotics and prebiotics can have a positive influence against infective processes such as that due to RV. The aim of this study was to evidence a preventive role of one prebiotic mixture (of short-chain galactooligosaccharide/long-chain fructooligosaccharide), the probiotic Bifidobacterium breve M-16V and the combination of the prebiotic and the probiotic, as a synbiotic, in a suckling rat double-RV infection model. Hyperimmune bovine colostrum was used as protection control. The first infection was induced with RV SA11 and the second one with EDIM. Clinical variables and immune response were evaluated after both infections. Dietary interventions ameliorated clinical symptoms after the first infection. The prebiotic and the synbiotic significantly reduced viral shedding after the first infection, but all the interventions showed higher viral load than in the RV group after the second infection. All interventions modulated ex vivo antibody and cytokine production, gut wash cytokine levels and small intestine gene expression after both infections. In conclusion, a daily supplement of the products tested in this preclinical model is highly effective in preventing RV-induced diarrhea but allowing the boost of the early immune response for a future immune response against reinfection, suggesting that these components may be potential agents for modulating RV infection in infants.

First Authors:
Maria Del Mar Rigo-Adrover

Correspondence Authors:
Francisco José Pérez-Cano

All Authors:
Maria Del Mar Rigo-Adrover,Kees van Limpt,Karen Knipping,Johan Garssen,Jan Knol,Adele Costabile,Àngels Franch,Margarida Castell,Francisco José Pérez-Cano

评论