北京大学团队:辛苦备孕的孕妇更需关注PM2.5暴露
创作:Epi汪 审核:Epi汪 09月17日
  • 纳入江苏省2451名孕妇数据,其中有69例自然流产,596例人工流产、1948例活产;
  • 分析自然流产发生风险与母亲暴露环境PM2.5之间的关联,发现孕期PM2.5暴露平均浓度每增加10ug/m3,自然流产的风险增加43.3%;
  • 在高龄产妇中,上述关联被削弱,提示低龄产妇更需关注PM2.5暴露造成的影响;
  • 对于意外怀孕的孕妇,上述关联被削弱,而计划怀孕的孕妇更需关注PM2.5暴露造成的影响。
主编推荐语
Epi汪
PM2.5暴露对妊娠期疾病的危害是常被关注和讨论的话题,本研究通过队列数据分析发现,孕期PM2.5暴露增加自然流产的风险,并且在认真备孕后怀孕的女性中更加明显,而意外妊娠的女性中这种关联被削弱。该结论具有一定创新性,值得进一步探讨。
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Association of maternal exposure to ambient particulate pollution with incident spontaneous pregnancy loss

孕妇暴露于环境颗粒物污染与自然流产事件的关系

10.1016/j.ecoenv.2021.112653

08-16, Article

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Background: Maternal exposure to ambient fine particulate matter (PM2.5) is a potential risk factor for pregnancy loss, but the extant findings are inconsistent. One reason for the inconsistency is the difficulty of distinguishing spontaneous from induced pregnancy losses, particularly in countries with planning policies.
Objective: To examine the association between maternal PM2.5 exposure and spontaneous incident pregnancy loss in China.
Methods: A total of 18,513 women of reproductive age was recruited from Jiangsu Province, China, in 2007. Among them, 2451 women reported 2613 valid records of incident pregnancies from 2007 to 2010. We used Cox regression to link the outcomes (live birth, spontaneous pregnancy loss, or induced abortion) of those incident pregnancies with maternal PM2.5 exposures, assessed using well-developed estimates of historical concentrations at the county level.
Results: Among the 2613 incident pregnancies, 69 spontaneous pregnancy losses, 596 induced abortions, and 1948 live births occurred. According to the adjusted model, each 10-μg/m3 increment in the average PM2.5 concentration during pregnancy was associated with a 43.3% (95% confidence interval, 6.6–92.5%) increased probability of spontaneous pregnancy loss. Advanced maternal age, a potential competing risk factor, weakened the association between PM2.5 and spontaneous pregnancy loss. The association was nonsignificant for unintended pregnancies.
Conclusion: Maternal PM2.5 exposure was associated significantly with incident spontaneous pregnancy loss. Our findings provide insight into the harmful effect of air pollution on human reproduction.

First Authors:
Huiyu Wang

Correspondence Authors:
Tao Xue

All Authors:
Huiyu Wang,Jiajianghui Li,Hengyi Liu,Fuyu Guo,Tao Xue,Tianjia Guan,Jiwei Li

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