同济秦环龙等Gut:大肠癌分子机制最新研究
  • 结直肠癌(CRC)相关长链非编码RNA—CCAL是CRC发生发展的重要调控因子;
  • 比较252名CRC患者的CCAL表达水平,发现与低表达CCAL的患者相比,高表达患者总生存期更短,对辅助化疗的响应更差;
  • CCAL通过靶向激活蛋白2α (AP-2α),激活Wnt/β-连环蛋白信号通路,上调MDR1/P-gp表达,诱导产生多药耐药性(MDR),进而促进CRC进程;
  • 组蛋白H3甲基化和去乙酰化参与了CRC发生发展过程中CCAL的上调;
  • CCAL或可用于预测CRC患者预后及治疗效果。
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蓝灿辉 | 热心肠先生
同济大学第十附属医院院长秦环龙教授和德克萨斯大学安德森肿瘤中心王华敏两位大牛的合作[赞]
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Gut [IF:19.819]

Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt/β-catenin signalling pathway via suppression of activator protein 2α

长非编码RNA CCAL通过抑制AP-2α激活Wnt/β-连环蛋白信号通路以调控结直肠癌的进展

10.1136/gutjnl-2014-308392

2015-05-20, Article

Abstract & Authors:展开

Abstract:收起
OBJECTIVE: Long non-coding RNAs (lncRNAs) are emerging as key molecules in cancers, yet their potential molecular mechanisms are not well understood. The objective of this study is to examine the expression and functions of lncRNAs in the development of colorectal cancer (CRC).
METHODS: LncRNA expression profiling of CRC, adenoma and normal colorectal tissues was performed to identify tumour-related lncRNAs involved in colorectal malignant transformation. Then, we used quantitative reverse transcription PCR assays to measure the tumour-related lncRNA and to assess its association with survival and response to adjuvant chemotherapy in 252 patients with CRC. The mechanisms of CCAL function and regulation in CRC were examined using molecular biological methods.
RESULTS: We identified colorectal cancer-associated lncRNA (CCAL) as a key regulator of CRC progression. Patients whose tumours had high CCAL expression had a shorter overall survival and a worse response to adjuvant chemotherapy than patients whose tumours had low CCAL expression. CCAL promoted CRC progression by targeting activator protein 2α (AP-2α), which in turn activated Wnt/β-catenin pathway. CCAL induced multidrug resistance (MDR) through activating Wnt/β-catenin signalling by suppressing AP-2α and further upregulating MDR1/P-gp expression. In addition, we found that histone H3 methylation and deacetylases contributed to the upregulation of CCAL in CRC.
CONCLUSIONS: Our results suggest that CCAL is a crucial oncogenic regulator involved in CRC tumorigenesis and progression.

First Authors:
Yanlei Ma

Correspondence Authors:
Huamin Wang,Huanlong Qin

All Authors:
Yanlei Ma,Yongzhi Yang,Feng Wang,Mary-Pat Moyer,Qing Wei,Peng Zhang,Zhe Yang,Weijie Liu,Huizhen Zhang,Niwei Chen,Hua Wang,Huamin Wang,Huanlong Qin

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