Cell子刊:肝脏对宿主-菌群互作有何核心作用?(长图+前景展望)
  • 肝脏从肠道、脾脏、心脏接收血液,对中间代谢、胆汁分泌、维持血液无菌、血清内稳态、异生物质解毒和免疫活动等生理功能有核心作用;
  • 肝脏清除渗透进血的微生物,代谢肠道微生物合成或改造的异生物质,同时菌群调节胆汁酸传递的信号;
  • 作为激素的胆汁酸,结合其他不同微生物分子对代谢控制无处不在的影响,强力塑造了肝脏代谢;
  • 此外,肠道微生物代谢产物能被定居在肝脏的免疫细胞感知,这可能破坏肝脏稳态,导致纤维化和肝癌。
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蓝灿辉 | 热心肠先生
今天出版的Cell Host & Microbe上另一篇必读的文章,系统性阐述肝脏是如何连接宿主和微生物的。这篇文章的学术性比较强,涉及分子通路比较多,为此我们没有专门将图编译为中文,但依然值得所有人看一看,读一读,强烈推荐!
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延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
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The Liver at the Nexus of Host-Microbial Interactions

在宿主-微生物相互作用中肝脏的连接作用

10.1016/j.chom.2016.10.016

2016-11-09, Review

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BACKGROUND: The liver receives blood from the intestine, from the spleen, and directly from the heart and holds a vital position in vertebrate physiology. It plays a role in intermediary metabolism, bile secretion, maintaining blood sterility, serum homeostasis, xenobiotic detoxification, and immunological activity. This article provides our perspective on the liver as a nexus in establishing and maintaining host microbial mutualism. We discuss the role of the liver not only in sanitizing the blood stream from penetrant live microbes, but also in metabolizing xenobiotics that are synthesized or modified by intestinal microbes, and how microbiota modify the signaling potential of bile acids. The combination of bile acids as hormones and the metabolic control from pervasive effects of other absorbed microbial molecules powerfully shape hepatic metabolism. In addition, intestinal microbial metabolites can be sensed by liver-resident immune cells, which may disturb liver homeostasis, leading to fibrosis and liver cancer.

First Authors:
Andrew J Macpherson

Correspondence Authors:
Andrew J Macpherson,Stephanie C Ganal-Vonarburg

All Authors:
Andrew J Macpherson,Mathias Heikenwälder,Stephanie C Ganal-Vonarburg

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