Nature:婴幼儿肠道菌群发育的3个阶段
  • 分析903名儿童3-46月龄的粪便菌群组成,可分为10个聚类;
  • 早期肠道菌群发育包括3个阶段:发育期(3-14月)、过渡期(15-30月)和稳定期(≥31月),菌群组成和功能与多种因素相关;
  • 母乳喂养对发育期菌群的影响最大,与双歧杆菌(尤其是两歧和短双歧杆菌)丰度较高相关,终止母乳导致以厚壁菌门增多为特征的菌群成熟;
  • 拟杆菌属丰度在顺产婴儿中较高,与菌群多样性较高和成熟较快相关;
  • 地理位置和家庭环境等也是影响菌群的重要因素。
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mildbreeze
Nature刚刚上线的第二篇基于TEDDY研究的论文,由美国贝勒医学院主导,用16S和宏基因组学法分析903名婴幼儿从3月龄至接近4岁期间的1.2万份粪便样本,主要总结了幼年期人体肠道菌群的发育特征,也分析了1型糖尿病相关的菌群因素,可与另一项研究(查看文章)搭配阅读。相关发现对于理解婴幼儿肠道菌群建立和发育规律、喂养方式对肠道菌群的影响,以及以此为基础的菌群相关疾病研究,都有重要参考价值,不过这些规律背后的生理意义和对健康的影响,仍需后续研究阐释。
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Nature [IF:42.778]

Temporal development of the gut microbiome in early childhood from the TEDDY study

来自TEDDY研究的幼儿期肠道微生物组的时间发育

10.1038/s41586-018-0617-x

2018-10-01, Article

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The development of the microbiome from infancy to childhood is dependent on a range of factors, with microbial-immune crosstalk during this time thought to be involved in the pathobiology of later life diseases such as persistent islet autoimmunity and type 1 diabetes. However, to our knowledge, no studies have performed extensive characterization of the microbiome in early life in a large, multi-centre population. Here we analyse longitudinal stool samples from 903 children between 3 and 46 months of age by 16S rRNA gene sequencing (n = 12,005) and metagenomic sequencing (n = 10,867), as part of the The Environmental Determinants of Diabetes in the Young (TEDDY) study. We show that the developing gut microbiome undergoes three distinct phases of microbiome progression: a developmental phase (months 3-14), a transitional phase (months 15-30), and a stable phase (months 31-46). Receipt of breast milk, either exclusive or partial, was the most significant factor associated with the microbiome structure. Breastfeeding was associated with higher levels of Bifidobacterium species (B. breve and B. bifidum), and the cessation of breast milk resulted in faster maturation of the gut microbiome, as marked by the phylum Firmicutes. Birth mode was also significantly associated with the microbiome during the developmental phase, driven by higher levels of Bacteroides species (particularly B. fragilis) in infants delivered vaginally. Bacteroides was also associated with increased gut diversity and faster maturation, regardless of the birth mode. Environmental factors including geographical location and household exposures (such as siblings and furry pets) also represented important covariates. A nested case-control analysis revealed subtle associations between microbial taxonomy and the development of islet autoimmunity or type 1 diabetes. These data determine the structural and functional assembly of the microbiome in early life and provide a foundation for targeted mechanistic investigation into the consequences of microbial-immune crosstalk for long-term health.

First Authors:
Christopher J Stewart,Nadim J Ajami

Correspondence Authors:
Christopher J Stewart,Joseph F Petrosino

All Authors:
Christopher J Stewart,Nadim J Ajami,Jacqueline L O'Brien,Diane S Hutchinson,Daniel P Smith,Matthew C Wong,Matthew C Ross,Richard E Lloyd,HarshaVardhan Doddapaneni,Ginger A Metcalf,Donna Muzny,Richard A Gibbs,Tommi Vatanen,Curtis Huttenhower,Ramnik J Xavier,Marian Rewers,William Hagopian,Jorma Toppari,Anette-G Ziegler,Jin-Xiong She,Beena Akolkar,Åke Lernmark,Heikki Hyöty,Kendra Vehik,Jeffrey P Krischer,Joseph F Petrosino

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Nature | TEDDY项目中早期儿童的肠道微生态的时序发展

菌探Momics,2018-11-27

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