蔡军+朱宝利+杨新春等:肠道菌群失衡促进高血压
  • 分析41名健康人、56名高血压前期和99名原发性高血压患者的宏基因组和代谢组;
  • 高血压前期和高血压患者的菌群失衡且非常类似,且均与宿主的代谢变化紧密相关;
  • 两个患者组均表现出:微生物丰度和多样性明显降低,普氏菌占优的肠型,有益菌明显降低而普氏菌和克雷伯氏菌过度生长,微生物功能与疾病关联;
  • 研究者建立了基于菌群并能从对照组准确区分高血压前期和高血压个体的分类器;
  • 将患者菌群转入无菌小鼠,发现小鼠血压升高。
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蓝灿辉 | 热心肠先生
蔡军+朱宝利+杨新春等团队合作的关于肠道菌群促进高血压发展的重要研究,强烈推荐阅读。
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Microbiome [IF:11.607]

Gut microbiota dysbiosis contributes to the development of hypertension

肠道菌群失衡促进高血压的发展

10.1186/s40168-016-0222-x

2017-02-01, Article

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BACKGROUND: Recently, the potential role of gut microbiome in metabolic diseases has been revealed, especially in cardiovascular diseases. Hypertension is one of the most prevalent cardiovascular diseases worldwide, yet whether gut microbiota dysbiosis participates in the development of hypertension remains largely unknown. To investigate this issue, we carried out comprehensive metagenomic and metabolomic analyses in a cohort of 41 healthy controls, 56 subjects with pre-hypertension, 99 individuals with primary hypertension, and performed fecal microbiota transplantation from patients to germ-free mice.
RESULTS: Compared to the healthy controls, we found dramatically decreased microbial richness and diversity, Prevotella-dominated gut enterotype, distinct metagenomic composition with reduced bacteria associated with healthy status and overgrowth of bacteria such as Prevotella and Klebsiella, and disease-linked microbial function in both pre-hypertensive and hypertensive populations. Unexpectedly, the microbiome characteristic in pre-hypertension group was quite similar to that in hypertension. The metabolism changes of host with pre-hypertension or hypertension were identified to be closely linked to gut microbiome dysbiosis. And a disease classifier based on microbiota and metabolites was constructed to discriminate pre-hypertensive and hypertensive individuals from controls accurately. Furthermore, by fecal transplantation from hypertensive human donors to germ-free mice, elevated blood pressure was observed to be transferrable through microbiota, and the direct influence of gut microbiota on blood pressure of the host was demonstrated.
CONCLUSIONS: Overall, our results describe a novel causal role of aberrant gut microbiota in contributing to the pathogenesis of hypertension. And the significance of early intervention for pre-hypertension was emphasized.

First Authors:
Jing Li,Fangqing Zhao,Yidan Wang,Junru Chen,Jie Tao

Correspondence Authors:
Xinchun Yang,Baoli Zhu,Jun Cai

All Authors:
Jing Li,Fangqing Zhao,Yidan Wang,Junru Chen,Jie Tao,Gang Tian,Shouling Wu,Wenbin Liu,Qinghua Cui,Bin Geng,Weili Zhang,Ryan Weldon,Kelda Auguste,Lei Yang,Xiaoyan Liu,Li Chen,Xinchun Yang,Baoli Zhu,Jun Cai

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