Science:中科院遗传发育所白洋组揭示植物塑造根系特异微生物组的机制
  • 植物近30%的光合作用产物合成根系化合物,它们如何参与特异根系微生物组的塑造一直没有答案;
  • 拟南芥中三萜合成基因簇在根系特异表达,并具有潜力合成50多种未知的根系化合物;
  • 与不能合成三萜的水稻和小麦相比,52%拟南芥特异的根系微生物组被三萜合成基因显著调控;
  • 通过分离培养的细菌资源库与纯化/合成的单种或混合化合物共培养,发现三萜化合物直接调控特异的根系细菌种类;
  • 根系细菌可以特异性修饰和利用拟南芥三萜化合物。
主编推荐语
刘永鑫-中科院遗传发育所-宏基因组
中国科学院遗传与发育生物学研究/植物和微生物科学中英联合研究中心白洋课题组,与英国约翰英纳斯中心的Anne Osbourn课题组合作,在《Science》上发表文章,揭示了拟南芥三萜类化合物对根系微生物组的调控规律,该研究为利用植物天然化合物促进根系益生菌在绿色农业中的应用提供了理论依据。黄安诚和姜婷为共同第一作者,刘永鑫负责本文的微生物组数据分析。
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Science [IF:41.037]

A specialized metabolic network selectively modulates Arabidopsis root microbiota

拟南芥三萜化合物特异调控根系微生物组

10.1126/science.aau6389

2019-05-10, Article

Abstract & Authors:展开

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Plant specialized metabolites have ecological functions, yet the presence of numerous uncharacterized biosynthetic genes in plant genomes suggests that many molecules remain unknown.We discovered a triterpene biosynthetic network in the roots of the small mustard plant Arabidopsis thaliana. Collectively, we have elucidated and reconstituted three divergent pathways for the biosynthesis of root triterpenes, namely thalianin (seven steps), thalianyl medium-chain fatty acid esters (three steps), and arabidin (five steps). A. thaliana mutants disrupted in the biosynthesis of these compounds have altered root microbiota. In vitro bioassays with purified compounds reveal selective growth modulation activities of pathway metabolites toward root microbiota members and their biochemical transformation and utilization by bacteria, supporting a role for this biosynthetic network in shaping an Arabidopsis-specific root microbial community.

First Authors:
Ancheng C Huang,Ting Jiang

Correspondence Authors:
Yang Bai,Anne Osbourn

All Authors:
Ancheng C Huang,Ting Jiang,Yong-Xin Liu,Yue-Chen Bai,James Reed,Baoyuan Qu,Alain Goossens,Hans-Wilhelm Nützmann,Yang Bai,Anne Osbourn

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Science:拟南芥三萜化合物特异调控根系微生物组

刘永鑫,2019-07-11

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