益生菌能否预防婴儿肠绞痛?
  • 使用OvidMEDLINE®,EMBASE®和Cochrane数据库进行文献检索,考察益生菌在治疗和预防婴儿肠绞痛中的应用;
  • 3项研究显示,肠绞痛婴儿和健康婴儿的肠道微生物群组成不同;
  • 在6项研究中,与安慰剂相比,补充益生菌和/或合生制剂显著降低了肠绞痛婴儿的哭闹和疼痛率;
  • 但在2项研究中,未检测到其与肠绞痛相关的烦躁不安的发生率和频率的关联;
  • 合并现有证据表明,益生菌和/或合生制剂可预防/治疗婴儿肠绞痛,可进一步推广该方案并验证。
主编推荐语
玉龙潭
婴儿肠绞痛影响多达20%的婴儿,尽管其发病机制目前尚不清楚,但一些假设是食物过敏或肠道运动障碍,以及炎症和内脏疼痛。益生菌在治疗和预防婴儿肠绞痛中的应用是一个相对较新的话题。本文检索了相关文献检索,发现有证据表明肠绞痛婴儿和健康婴儿的肠道微生物群组成存在差异,认为使用益生菌和合生元或是预防和治疗婴儿腹绞痛的实用策略。
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Gastroenterology [IF:33.883]

Prevention of Infantile Colic Using Probiotics

益生菌预防婴儿肠绞痛

2018-12-01, Other

Abstract & Authors:展开

Abstract:收起
Objective: Infantile colic is a frustrating impasse that affects up to 20% of infants. Even though its pathogenesis is currently unknown, some hypotheses are food hypersensitivity or allergy, gut dysmotility, inflammation, and visceral pain. The use of probiotics in treatment and prevention of infantile colic is a relatively new topic.
Method: Literature searches were conducted using Ovid MEDLINE®, EMBASE®, and the Cochrane Central Register of Controlled Trials. Randomised controlled trials including the terms “neonate(s)”, “infant(s)”, “probiotics”, “synbiotics”, “Lactobacillus”, “Bifidobacterium”, “colic”, and “prevention” were included.
Results: Three studies showed the different composition of intestinal microbiota between colicky infants and control groups. In six of the studies, probiotic and/or synbiotic supplementation significantly decreased the rate of crying and pain in colicky infants compared with placebo; however, in two studies, no effect on the incidence and frequency of colic-related restlessness was detected. In all, the reviewed studies demonstrated that probiotic and/or symbiotic treatment regimens were effective for infantile colic prevention.
Conclusions: There is much evidence suggestive of diversity in the intestinal microbiota among colicky and healthy infants. Based on recent research, using probiotics and synbiotics is a practical and favourable strategy for prevention and treatment of fussiness in colicky infants.

First Authors:
Hamid Ahanchian

Correspondence Authors:
Hamid Ahanchian

All Authors:
Hamid Ahanchian,Asma Javid

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