Cell子刊:饮食如何影响癌细胞代谢?(综述)
创作:Lexi 审核:Lexi 2020年06月22日
  • 饮食成分影响循环代谢因子和营养物质可利用性,进而影响癌细胞代谢;
  • 热量限制(CR)或禁食被证明对癌症防治有益,但是否因潜在代谢依赖产生负面影响尚无定论;
  • 无严格证据表明低碳和生酮饮食(KDs)可降低癌症发病率或改善预后,需更多研究揭示饮食中常量营养素对癌症的影响;
  • 循环氨基酸在癌细胞中代谢,为肿瘤提供独特的生物合成和能量需求;
  • 微生物在癌症中的作用尚未明确,但饮食驱动的肠道菌群变化与肿瘤形成、进展和治疗有关。
主编推荐语
Lexi
癌细胞改变其代谢方式以满足不受控制的细胞增殖的需求,这些需求导致其在能量、生物合成前体和信号中间体方面的不同需求。遗传事件和表观遗传事件在提供必要的代谢网络活动中都是至关重要的。越来越多的证据表明,环境因素在塑造癌细胞代谢过程中起着重要作用。就代谢而言,饮食和营养是主要的环境因素,并已成为决定癌细胞代谢的关键因素。最新发表在《Molecular Cell》的这篇综述讨论了肿瘤代谢的概念,以及饮食和营养如何影响癌细胞代谢。
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Molecular Cell [IF:15.584]

The Molecular Link from Diet to Cancer Cell Metabolism

饮食和癌细胞代谢的分子联系

10.1016/j.molcel.2020.05.018

2020-06-05, Review

Abstract & Authors:展开

Abstract:收起
Malignant cells remodel their metabolism to meet the demands of uncontrolled cell proliferation. These demands lead to differential requirements in energy, biosynthetic precursors, and signaling intermediates. Both genetic programs arising from oncogenic events and transcriptional programs and epigenomic events are important in providing the necessary metabolic network activity. Accumulating evidence has established that environmental factors play a major role in shaping cancer cell metabolism. For metabolism, diet and nutrition are the major environmental aspects and have emerged as key components in determining cancer cell metabolism. In this review, we discuss these emerging concepts in cancer metabolism and how diet and nutrition influence cancer cell metabolism.

First Authors:
Shree Bose

Correspondence Authors:
Jason W Locasale

All Authors:
Shree Bose,Annamarie E Allen,Jason W Locasale

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