Nature子刊:特定细菌裂解物或可改善菌群和免疫代谢稳态!
创作:Vera 审核:Vera 2021年03月09日
  • McB细菌裂解物可恢复高脂高糖的西式饮食(WD)小鼠的肠道菌群改变,使其转向低脂喂养的“瘦样”菌群组成;
  • McB治疗WD小鼠,增加了短链脂肪酸的水平,缓解了饮食诱导的肥胖;
  • 基于McB的饮食改善了葡萄糖代谢,降低了体脂和肝脂,降低肝脏免疫细胞浸润,缓解了非酒精性脂肪肝;
  • McB饮食显著富集了副杆菌属的丰度,使FoxP3+RORγt+IL-17+ 调节性T细胞增多;
  • 该研究揭示了通过McB裂解物改善免疫代谢平衡的潜力。
主编推荐语
Vera
近年来,通过微生物来调节改善肠道免疫代谢平衡状态似乎很有前景,但是仍然存在很多问题,例如粪菌移植和益生菌研究中存在的应答率不一致性以及偶发不良事件,都说明了该治疗方案的复杂性。因此,特定细菌裂解物(细菌的溶解产物)、细菌的特定组分或者灭活菌,成为了潜在的可替代方案。Nature Communications近期发表的一项研究发现,在西式饮食喂养的小鼠中,喂食荚膜甲基球菌(McB)的细菌裂解物可显著改善饮食诱导的肠道菌群失调和免疫代谢紊乱等表型,为用细菌裂解物治疗疾病的方案奠定了基础。
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Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism

荚膜甲基球菌(McB)裂解物可诱导瘦样肠道菌群组成的改变,肠FoxP3+RORγt+IL-17+ Tregs细胞并改善代谢状态

10.1038/s41467-021-21408-9

2021-02-17, Article

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Abstract:收起
Interactions between host and gut microbial communities are modulated by diets and play pivotal roles in immunological homeostasis and health. We show that exchanging the protein source in a high fat, high sugar, westernized diet from casein to whole-cell lysates of the non-commensal bacterium Methylococcus capsulatus Bath is sufficient to reverse western diet-induced changes in the gut microbiota to a state resembling that of lean, low fat diet-fed mice, both under mild thermal stress (T22 °C) and at thermoneutrality (T30 °C). Concomitant with microbiota changes, mice fed the Methylococcus-based western diet exhibit improved glucose regulation, reduced body and liver fat, and diminished hepatic immune infiltration. Intake of the Methylococcu-based diet markedly boosts Parabacteroides abundances in a manner depending on adaptive immunity, and upregulates triple positive (Foxp3+RORγt+IL-17+) regulatory T cells in the small and large intestine. Collectively, these data point to the potential for leveraging the use of McB lysates to improve immunometabolic homeostasis.

First Authors:
Benjamin A H Jensen,Karsten Kristiansen,Tor E Lea

Correspondence Authors:
Benjamin A H Jensen,Karsten Kristiansen,Tor E Lea

All Authors:
Benjamin A H Jensen,Jacob B Holm,Ida S Larsen,Nicole von Burg,Stefanie Derer,Si B Sonne,Simone I Pærregaard,Mads V Damgaard,Stine A Indrelid,Aymeric Rivollier,Anne-Laure Agrinier,Karolina Sulek,Yke J Arnoldussen,Even Fjære,André Marette,Inga L Angell,Knut Rudi,Jonas T Treebak,Lise Madsen,Caroline Piercey Åkesson,William Agace,Christian Sina,Charlotte R Kleiveland,Karsten Kristiansen,Tor E Lea

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