Cell子刊:噬菌体-细菌-宿主互作研究新进展(综述)
创作:大月半 审核:周旸 03月31日
  • 噬菌体、细菌和人类宿主三者相互作用可以影响机体健康和疾病状态;
  • 噬菌体可以作为靶向特定肠道致病菌的抗菌剂,同时能影响肠道外其他组织和器官生理功能;
  • 利用噬菌体特异性开发纳米材料药物递送系统、噬菌体酶修饰,可用于一系列治疗用化合物和药物的精确递送;
  • 噬菌体可以间接通过原核细菌、或直接通过噬菌体内化和受体识别,影响宿主细胞免疫功能;
  • 宿主免疫反应又可以影响共生细菌和噬菌体,三者共同影响人类疾病状态。
主编推荐语
周旸
越来越多的研究表明噬菌体-细菌-人类宿主形成了三方相互作用,有可能影响人体的健康和疾病状态。Cell Host and Microbe近期发表小综述,系统性回顾了噬菌体影响人体共生微生态以及人体本身状态的机制,着重介绍了噬菌体参与微生态调控、药物递呈的研究进展。本文对于了解共生病毒-共生细菌-宿主免疫之间的最新进展具有重要参考价值。
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Rethinking phage-bacteria-eukaryotic relationships and their influence on human health

重新审视噬菌体-细菌-宿主相互关系及对人类健康的影响

10.1016/j.chom.2021.02.007

03-17, Article

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Abstract:收起
There is a rapidly growing body of research demonstrating the unique and often surprising mechanisms by which bacteriophages, specialized viruses of bacteria, can influence human health and disease states. This can occur directly by shaping their bacterial host’s ecology through top-down pressure or via more indirect routes, including influencing the human body’s metabolism or immune system. These microbial interactions can affect health and disease states in both the local environment or by influencing the body’s distal organs or systems. Here we provide an update on the current understanding of bacteriophages’ influence on human health within the context of tripartite symbioses with their bacterial and human hosts.

First Authors:
Adam Wahida,Fang Tang

Correspondence Authors:
Adam Wahida,Fang Tang

All Authors:
Adam Wahida,Fang Tang,Jeremy J Barr

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