孕期空气污染高,儿童肥胖?仍无定论!
  • 纳入1125对母婴数据,记录新生儿出生时及5月时的脂肪量、游离脂肪量等指标,根据居住地址记录孕期PM2.5、O3等空气污染物暴露情况;
  • 总体来说,孕期空气污染暴露与婴儿出生结局关联较弱;
  • 仅在孕晚期,观察到O3暴露浓度与婴儿5月时肥胖风险呈正相关,与出生后脂肪量增长速度呈正相关;
  • 上述关联在性别间无交互作用;
  • 居住点与高速公路的距离、与主要交通干道距离以及交通密度等与儿童肥胖的关联暂未被发现。
主编推荐语
小笋干儿
本研究利用人群样本数据试图探索孕期居住环境周围的空气污染情况与后代儿童肥胖之间的关联。但是除了O3的浓度与儿童肥胖具有微弱的关联外,其他关联均无统计学意义。
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延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!

Prenatal exposure to traffic and ambient air pollution and infant weight and adiposity: The Healthy Start study

产前暴露交通和周围空气污染与儿童体重及肥胖的关联:健康起始研究

10.1016/j.envres.2020.109130

03-01, Article

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Background: Prenatal exposures to ambient air pollution and traffic have been associated with adverse birth outcomes, and may also lead to an increased risk of obesity. Obesity risk may be reflected in changes in body composition in infancy.
Objective: To estimate associations between prenatal ambient air pollution and traffic exposure, and infant weight and adiposity in a Colorado-based prospective cohort study.
Methods: Participants were 1125 mother-infant pairs with term births. Birth weight was recorded from medical records and body composition measures (fat mass, fat-free mass, and adiposity [percent fat mass]) were evaluated via air displacement plethysmography at birth (n = 951) and at ~5 months (n = 574). Maternal residential address was used to calculate distance to nearest roadway, traffic density, and ambient concentrations of fine particulate matter (PM2.5) and ozone (O3) via inverse-distance weighted interpolation of stationary monitoring data, averaged by trimester and throughout pregnancy. Adjusted linear regression models estimated associations between exposures and infant weight and body composition.
Results: Participants were urban residents and diverse in race/ethnicity and socioeconomic status. Average ambient air pollutant concentrations were generally low; the median, interquartile range (IQR), and range of third trimester concentrations were 7.3 μg/m3 (IQR: 1.3, range: 3.3–12.7) for PM2.5 and 46.3 ppb (IQR: 18.4, range: 21.7–63.2) for 8-h maximum O3. Overall there were few associations between traffic and air pollution exposures and infant outcomes. Third trimester O3 was associated with greater adiposity at follow-up (2.2% per IQR, 95% CI 0.1, 4.3), and with greater rates of change in fat mass (1.8 g/day, 95% CI 0.5, 3.2) and adiposity (2.1%/100 days, 95% CI 0.4, 3.7) from birth to follow-up.

First Authors:
Anne P Starling

Correspondence Authors:
Anne P Starling

All Authors:
Anne P Starling,Brianna F Moore,Deborah SK Thomas,Jennifer L Peel,Weiming Zhang,John L Adgate,Sheryl Magzamen,Sheena E Martenies,William B Allshouse,Dana Dabele

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