上交+上海中医院等:脾阳虚证患者的代谢和菌群特征
  • 脾阳虚证(SYDS)是中医常见病证,反映消化问题引发的整体代谢变化;
  • SYDS患者和健康个体各30例,分析血浆和尿液的代谢谱和粪菌组成;
  • 与健康对照相比,SYDS患者菌群中厚壁菌门增多、拟杆菌门减少,菌群组成有显著变化,血浆和尿液中多个代谢通路被扰动;
  • 综合分析菌群与代谢物,鉴定出norank_f_CFT112H7,f_lachnospiraceae和拟杆菌属与宿主粘膜完整性、胆汁酸代谢和多糖分解相关;
  • 肠道菌群对SYDS患者的代谢紊乱有潜在贡献。
主编推荐语
mildbreeze
上海交大张卫东和上海市中医院李毅平共同主导的研究,分析了脾阳虚证(SYDS)患者的代谢和菌群特征。这是少有的从肠道菌群和代谢谱的综合角度,对中医常见病证的研究,值得关注。
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Scientific Reports [IF:3.998]

Integrative metabolic and microbial profiling on patients with Spleen-yang-deficiency syndrome

脾阳虚证患者的综合代谢和微生物分析

10.1038/s41598-018-24130-7

2018-04-26, Article

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Gut microbiota is recognized as an indispensable “metabolic organ” that plays crucial roles in maintaining human health or initiating diseases. Spleen-yang-deficiency syndrome (SYDS) is a common syndrome of Traditional Chinese Medicine (TCM) clinic. It is a complex phenotype reflecting the overall changes of metabolism which are mainly caused by digestive disorders. However, little is known about the changes of gut microbiota and metabolism in patients with SYDS, as well as the crosstalk between gut microbiota and host metabolism. In the current study, an integrative metabolic and microbial profiling was performed on plasma, urine and feces from recruited SYDS and healthy individuals by using a LC-QTOFMS-based metabolomic and 16 s rRNA sequencing approaches. Our results showed a potentially significant contribution of gut dysbiosis to the metabolic disorders in SYDS. By integrating the differential gut bacteria with the metabolites, the results revealed some active bacterium of norank_f_CFT112H7, f_lachnospiraceae and bacteroides were closely involved in host mucosal integrity, bile acid metabolism and polysaccharides decomposition. Therefore, our results indicated the probable involvement of gut microbiota in mediating the metabolic changes, which warrants a further investigation on the role of gut microbiota in modulating the pathogenesis of SYDS.

First Authors:
Zhang Lin

Correspondence Authors:
Yiping Li,Weidong Zhang

All Authors:
Zhang Lin,Wu Ye,Xianpeng Zu,Haisheng Xie,Houkai Li,Yiping Li,Weidong Zhang

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